UniProt Q9BV86
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (Q9BV86)
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (UniProt Q9BV86), EC 2.1.1.244: 33 experimental structures on GenesisL1, 10 ligands bound, 43 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9BV86
- Protein
- N-terminal Xaa-Pro-Lys N-methyltransferase 1
- EC
- 2.1.1.244
- Experimental structures
- 33
- Predicted models
- 0
- Ligands
- 10
- Pockets
- 43 · 10 records with a druggable one
Structures
33 records of Q9BV86 in the MolNFT archive: 33 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2EX4 | Crystal Structure of Human methyltransferase AD-003 in complex with S-adenosyl-L-homocysteine | x-ray diffraction | A, B | — | — |
| 2EX4 | Crystal structure of human methyltransferase ad-003 in complex with S-adenosyl-L-homocysteine | x-ray diffraction | A, B | — | — |
| 5CVD | Crystal structure of human NRMT1 in complex with alpha-N-dimethylated human CENP-A peptide | x-ray diffraction | A, B | SAH | 5 (best 0.80) |
| 5CVD | Crystal structure of human NRMT1 in complex with alpha-N-dimethylated human cenp-a peptide | x-ray diffraction | A, B | — | — |
| 5CVE | Crystal Structure of human NRMT1 in complex with dimethylated fly H2B peptide and SAH | x-ray diffraction | A, B | — | — |
| 5CVE | Crystal structure of human NRMT1 in complex with dimethylated fly H2B peptide and sah | x-ray diffraction | A, B | — | — |
| 5E1B | Crystal structure of NRMT1 in complex with SPKRIA peptide | x-ray diffraction | A, B | UNX | — |
| 5E1B | Crystal structure of NRMT1 in complex with spkria peptide | x-ray diffraction | A, B | — | — |
| 5E1D | NTMT1 in complex with YPKRIA peptide | x-ray diffraction | A, B | UNX | — |
| 5E1D | NTMT1 in complex with ypkria peptide | x-ray diffraction | A, B | — | — |
| 5E1M | Crystal structure of NTMT1 in complex with PPKRIA peptide | x-ray diffraction | A, B | SAH, UNX | 6 (best 0.80) |
| 5E1M | Crystal structure of NTMT1 in complex with ppkria peptide | x-ray diffraction | A, B | — | — |
| 5E1O | Crystal structure of NTMT1 in complex with RPKRIA peptide | x-ray diffraction | A, B | UNX | — |
| 5E1O | Crystal structure of NTMT1 in complex with rpkria peptide | x-ray diffraction | A, B | — | — |
| 5E2A | Crystal structure of NTMT1 in complex with N-terminally methylated SPKRIA peptide | x-ray diffraction | A, B | SAH, UNX | 6 (best 0.80) |
| 5E2A | Crystal structure of NTMT1 in complex with N-terminally methylated spkria peptide | x-ray diffraction | A, B | — | — |
| 5E2B | Crystal structure of NTMT1 in complex with N-terminally methylated PPKRIA peptide | x-ray diffraction | A, B | SAH, UNX | 5 (best 0.80) |
| 5E2B | Crystal structure of NTMT1 in complex with N-terminally methylated ppkria peptide | x-ray diffraction | A, B | — | — |
| 6DTN | The structure of NTMT1 in complex with compound DC100-1 | x-ray diffraction | B | — | 2 (best 0.79) |
| 6DTN | The structure of NTMT1 in complex with compound DC100-1 | x-ray diffraction | B | 6D6 | — |
| 6KDQ | Crystal structure of human NRMT1 in complex with alpha-N-monomethylated human CENP-A peptide | x-ray diffraction | A, B | SAH | 5 (best 0.79) |
| 6KDQ | Crystal structure of human NRMT1 in complex with alpha-N- monomethylated human cenp-a peptide | x-ray diffraction | A, B | — | — |
| 6PVA | The structure of NTMT1 in complex with compound 11 | x-ray diffraction | B | — | — |
| 6PVA | The structure of NTMT1 in complex with compound 11 | x-ray diffraction | B | 6D6, NH2 | — |
| 6PVB | The structure of NTMT1 in complex with compound 6 | x-ray diffraction | B | SAH | 2 (best 0.79) |
| 6PVB | The structure of NTMT1 in complex with compound 6 | x-ray diffraction | B | P2J | — |
| 6WH8 | The structure of NTMT1 in complex with compound BM-30 | x-ray diffraction | B, A | SAH | 4 (best 0.80) |
| 6WH8 | The structure of NTMT1 in complex with compound bm-30 | x-ray diffraction | B, A | 4HP | — |
| 6WJ7 | The structure of NTMT1 in complex with compound C2A | x-ray diffraction | B | AN6 | — |
| 7K3D | The structure of NTMT1 in complex with compound DC1-13 | x-ray diffraction | B, A | VWP | — |
| 7SS1 | The structure of NTMT1 in complex with compound GD433 | x-ray diffraction | A, B | SAH, AKF | 5 (best 0.80) |
| 7U1M | Crystal structure of NTMT1 in complex with compound YD206 | x-ray diffraction | A, B | SAH, KYF | 3 (best 0.80) |
| Q9BV86 | AlphaFold monomer V2.0 prediction for N-terminal xaa-pro-lys N-methyltransferase 1 (Q9BV86) | — | — | — |
Ligands
- SAH · S-adenosyl-L-homocysteine · in 9 records
- UNX · Unknown atom or ion · in 6 records
- 6D6 · 5'-{[(3S)-3-amino-3-carboxypropyl](3-aminopropyl) amino}-5'-deoxyadenosine · in 2 records
- 4HP · 4-hydroxyphenylacetate · in 1 record
- AKF · (1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl {2-[2-(4-fluoro-3-hydroxyphenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate · in 1 record
- AN6 · 5'-{[(3S)-3-amino-3-carboxypropyl](ethyl)amino}-5'-deoxyadenosine · in 1 record
- KYF · (1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl {2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate · in 1 record
- NH2 · Amino group · in 1 record
- P2J · 9-(5-{[(3S)-3-amino-3-carboxypropyl](pentyl)amino}-5-deoxy-beta-L-arabinofuranosyl)-9H-purin-6-amine · in 1 record
- VWP · N~2~-{(2S)-1-[(naphthalen-1-yl)acetyl]-2,5-dihydro-1H-pyrrole-2-carbonyl}-L-lysyl-L-argininamide · in 1 record
Elsewhere
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