UniProt Q9BE39
Myosin-7 (Q9BE39)
Myosin-7 (UniProt Q9BE39): 13 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 141 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9BE39
- Protein
- Myosin-7
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 141 · 10 records with a druggable one
Structures
14 records of Q9BE39 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5N69 | Cardiac muscle myosin S1 fragment in the pre-powerstroke state co-crystallized with the activator… | x-ray diffraction | A, B | ADP, VO4, MG, 2OW, TCE | 20 (best 0.88) |
| 5N69 | Cardiac muscle myosin S1 fragment in the pre-powerstroke state co- crystallized with the activator… | x-ray diffraction | A, B | ADP, VO4, MG, 2OW, TCE | — |
| 5N6A | Cardiac muscle myosin motor domain in the pre-powerstroke state | x-ray diffraction | A | ADP, PO4, MG | 7 (best 0.73) |
| 5N6A | Cardiac muscle myosin motor domain in the pre-powerstroke state | x-ray diffraction | A | ADP, PO4, MG | — |
| 6FSA | Beta-Cardiac myosin post-rigor | x-ray diffraction | A, B | MG, ADP | 20 (best 0.80) |
| 6FSA | Beta-cardiac myosin post-rigor | x-ray diffraction | A, B | MG, ADP | — |
| 6X5Z | Bovine Cardiac Myosin in Complex with Chicken Skeletal Actin and Human Cardiac Tropomyosin in the… | electron microscopy | G, D, J | — | 20 (best 0.85) |
| 6X5Z | Bovine cardiac myosin in complex with chicken skeletal actin and human cardiac tropomyosin in the… | electron microscopy | G, D, J | — | — |
| 8QYP | Beta-cardiac myosin motor domain in the pre-powerstroke state | x-ray diffraction | A | ADP, VO4, MG | 7 (best 0.74) |
| 8QYQ | Beta-cardiac myosin S1 fragment in the pre-powerstroke state complexed to Mavacamten | x-ray diffraction | A, B | ADP, BEF, MG, XB2 | 18 (best 0.86) |
| 8QYR | Beta-cardiac myosin motor domain in the pre-powerstroke state complexed to Mavacamten | x-ray diffraction | B | XB2, SO4, MG, ADP, BEF | 5 (best 0.78) |
| 8QYU | Beta-cardiac myosin S1 fragment in the pre-powerstroke state complexed to Omecamtiv mecarbil | x-ray diffraction | A, B | ADP, VO4, MG, 2OW | 20 (best 0.85) |
| 9F6C | Cardiac myosin motor domain in the pre-powerstroke state co-crystallized with the inhibitor… | x-ray diffraction | A, B | SO4, MG, 6I6, ADP, VO4 | 16 (best 0.77) |
| Q9BE39 | AlphaFold monomer V2.0 prediction for myosin-7 (Q9BE39) | predicted | A | — | 8 (best 0.78) |
Ligands
- ADP · Adenosine-5'-diphosphate · in 11 records
- MG · Magnesium ion · in 11 records
- VO4 · Vanadate ion · in 5 records
- 2OW · Methyl 4-(2-fluoro-3-{[(6-methylpyridin-3-yl) carbamoyl]amino}benzyl)piperazine-1-carboxylate · in 3 records
- BEF · Beryllium trifluoride ion · in 2 records
- PO4 · Phosphate ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- TCE · 3,3',3''-phosphanetriyltripropanoic acid · in 2 records
- XB2 · 6-[[(1~{S})-1-phenylethyl]amino]-3-propan-2-yl-1~{H}-pyrimidine-2,4-dione · in 2 records
- 6I6 · aficamten · in 1 record
Experiment against prediction
- 8QYR chain B against the predicted model Q9BE39: TM-score 0.99, RMSD 1.17 Å
- 9F6C chain A against the predicted model Q9BE39: TM-score 0.98, RMSD 1.29 Å
- 9F6C chain B against the predicted model Q9BE39: TM-score 0.98, RMSD 1.25 Å
- 8QYP chain A against the predicted model Q9BE39: TM-score 0.98, RMSD 1.28 Å
- 8QYQ chain B against the predicted model Q9BE39: TM-score 0.97, RMSD 1.73 Å
- 8QYU chain B against the predicted model Q9BE39: TM-score 0.97, RMSD 1.87 Å
- 8QYQ chain A against the predicted model Q9BE39: TM-score 0.96, RMSD 1.74 Å
- 5N69 chain B against the predicted model Q9BE39: TM-score 0.96, RMSD 1.89 Å
- 5N69 chain B against the predicted model Q9BE39: TM-score 0.96, RMSD 1.89 Å
- 5N69 chain A against the predicted model Q9BE39: TM-score 0.96, RMSD 1.83 Å
Elsewhere
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