UniProt Q99627
COP9 signalosome complex subunit 8 (Q99627)
COP9 signalosome complex subunit 8 (UniProt Q99627): 15 experimental structures and 1 predicted model on GenesisL1, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q99627
- Protein
- COP9 signalosome complex subunit 8
- Experimental structures
- 15
- Predicted models
- 1
- Pockets
- 13 · 5 records with a druggable one
Structures
16 records of Q99627 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4D10 | Crystal structure of the COP9 signalosome | x-ray diffraction | H, P | — | — |
| 4D10 | Crystal structure of the COP9 signalosome | x-ray diffraction | H, P | — | — |
| 4D18 | Crystal structure of the COP9 signalosome | x-ray diffraction | H, P | — | — |
| 4D18 | Crystal structure of the COP9 signalosome | x-ray diffraction | H, P | — | — |
| 4WSN | Crystal structure of the COP9 signalosome, a P1 crystal form | x-ray diffraction | H, P, X, f, n, v | — | — |
| 6R6H | Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome | electron microscopy | H | — | 2 (best 0.78) |
| 6R6H | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | H | — | — |
| 6R7F | Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome | electron microscopy | H | — | 2 (best 0.81) |
| 6R7F | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | H | — | — |
| 6R7H | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | H | — | — |
| 6R7I | Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome | electron microscopy | H | — | 3 (best 0.87) |
| 6R7I | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | H | — | — |
| 6R7N | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | H | — | — |
| 8H3A | Cryo-EM Structure of the KBTBD2-CRL3~N8(removed)-CSN complex | electron microscopy | H | — | 3 (best 0.85) |
| 8H3F | Cryo-EM Structure of the KBTBD2-CRL3-CSN complex | electron microscopy | H | — | 3 (best 0.83) |
| Q99627 | AlphaFold monomer V2.0 prediction for COP9 signalosome complex subunit 8 (Q99627) | predicted | A | — | — |
Experiment against prediction
- 4D18 chain H against the predicted model Q99627: TM-score 0.96, RMSD 1.11 Å
- 4D18 chain H against the predicted model Q99627: TM-score 0.96, RMSD 1.11 Å
- 4WSN chain X against the predicted model Q99627: TM-score 0.96, RMSD 1.09 Å
- 4WSN chain P against the predicted model Q99627: TM-score 0.96, RMSD 1.11 Å
- 4D10 chain P against the predicted model Q99627: TM-score 0.95, RMSD 1.17 Å
- 4D10 chain P against the predicted model Q99627: TM-score 0.95, RMSD 1.17 Å
- 4D10 chain H against the predicted model Q99627: TM-score 0.95, RMSD 1.19 Å
- 4D10 chain H against the predicted model Q99627: TM-score 0.95, RMSD 1.19 Å
- 4WSN chain f against the predicted model Q99627: TM-score 0.95, RMSD 1.22 Å
- 4D18 chain P against the predicted model Q99627: TM-score 0.95, RMSD 1.29 Å
Elsewhere
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