UniProt Q99558
Mitogen-activated protein kinase kinase kinase 14 (Q99558)
Mitogen-activated protein kinase kinase kinase 14 (UniProt Q99558), EC 2.7.11.25: 14 experimental structures on GenesisL1, 5 ligands bound, 17 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q99558
- Protein
- Mitogen-activated protein kinase kinase kinase 14
- EC
- 2.7.11.25
- Experimental structures
- 14
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 17 · 3 records with a druggable one
Structures
14 records of Q99558 in the MolNFT archive: 14 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4DN5 | Crystal Structure of NF-kB-inducing Kinase (NIK) | x-ray diffraction | A, B | — | — |
| 4DN5 | Crystal structure of nf-kb-inducing kinase (nik) | x-ray diffraction | A, B | — | — |
| 4G3D | Crystal structure of human NF-kappaB inducing kinase (NIK) | x-ray diffraction | A, B, D, E | — | — |
| 4G3D | Crystal structure of human nf-kappab inducing kinase (nik) | x-ray diffraction | A, B, D, E | — | — |
| 4IDT | Crystal Structure of NIK with 11-bromo-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-2… | x-ray diffraction | A, B | — | — |
| 4IDT | Crystal structure of nik with 11-bromo-5,6,7,8-TETRAHYDROPYRIMIDO[4'… | x-ray diffraction | A, B | — | — |
| 4IDV | Crystal Structure of NIK with compound 4-{3-[2-amino-5-(2-methoxyethoxy)pyrimidin-4-yl]-1H-indol-5-y… | x-ray diffraction | A, B, C, D | — | — |
| 4IDV | Crystal structure of nik with compound 4-{3-[2-amino-5-(2… | x-ray diffraction | A, B, C, D | — | — |
| 6WPP | Human nik in complex with ligand compound X | x-ray diffraction | A, B | PZ4 | — |
| 6WPP | Human nik in complex with ligand compound X | x-ray diffraction | A, B | PZ4 | — |
| 6Z1Q | MAP3K14 (NIK) in complex with DesF-3R/4076 | x-ray diffraction | AAA, BBB | Q58 | 3 (best 0.76) |
| 6Z1T | MAP3K14 (NIK) in complex with 4S/3694 | x-ray diffraction | AAA, BBB | Q55 | 2 (best 0.78) |
| 8YHW | The Crystal Structure of NF-kB-inducing Kinase (NIK) from Biortus | x-ray diffraction | A, B, C, D | AGS, MG | 12 (best 0.80) |
| Q99558 | AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase kinase kinase 14 (Q99558) | — | — | — |
Ligands
Elsewhere
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