UniProt Q99496
E3 ubiquitin-protein ligase RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (UniProt Q99496), EC 2.3.2.27: 21 experimental structures on GenesisL1, 2 ligands bound, 9 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q99496
- Protein
- E3 ubiquitin-protein ligase RING2
- EC
- 2.3.2.27
- Experimental structures
- 21
- Predicted models
- 0
- Ligands
- 2
- Pockets
- 9 · 5 records with a druggable one
Structures
21 records of Q99496 in the MolNFT archive: 21 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2H0D | Structure of a Bmi-1-Ring1B Polycomb group ubiquitin ligase complex | x-ray diffraction | B | — | — |
| 2H0D | Structure of a bmi-1-RING1B polycomb group ubiquitin ligase complex | x-ray diffraction | B | — | — |
| 3GS2 | Ring1B C-terminal domain/Cbx7 Cbox Complex | x-ray diffraction | A, C | — | — |
| 3GS2 | RING1B C-terminal DOMAIN/CBX7 cbox complex | x-ray diffraction | A, C | — | — |
| 3H8H | Structure of the C-terminal domain of human RNF2/RING1B; | x-ray diffraction | A | — | — |
| 3H8H | Structure of the C-terminal domain of human RNF2/RING1B; | x-ray diffraction | A | — | — |
| 3IXS | Ring1B C-terminal domain/RYBP C-terminal domain Complex | x-ray diffraction | A, C, E, G, I, K | — | — |
| 3IXS | RING1B C-terminal DOMAIN/RYBP C-terminal domain complex | x-ray diffraction | A, C, E, G, I, K | — | — |
| 3RPG | Bmi1/Ring1b-UbcH5c complex structure | x-ray diffraction | C | — | — |
| 3RPG | BMI1/RING1B-UBCH5C complex structure | x-ray diffraction | C | — | — |
| 4R8P | Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core… | x-ray diffraction | L, N | — | — |
| 4R8P | Crystal structure of the RING1B/BMI1/UBCH5C PRC1 ubiquitylation module bound to the nucleosome core… | x-ray diffraction | L, N | — | — |
| 4S3O | PCGF5-RING1B-UbcH5c complex | x-ray diffraction | B, E | — | — |
| 4S3O | PCGF5-RING1B-UBCH5C complex | x-ray diffraction | B, E | — | — |
| 7ND1 | First-in-class small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) RING domain | solution nmr | A | ZN, U9E | 3 (best 0.52) |
| 7ND1 | First-in-class small molecule inhibitors of polycomb repressive complex 1 (PRC1) ring domain | solution nmr | A | ZN, U9E | — |
| 8GRM | Cryo-EM structure of PRC1 bound to H2AK119-UbcH5b-Ub nucleosome | electron microscopy | N | ZN | 3 (best 0.76) |
| 9DBY | ncPRC1RYBP bound to singly modified H2AK119Ub nucleosome | electron microscopy | L | ZN | 1 (best 0.68) |
| 9DDE | ncPRC1RYBP bound to H2AK119Ub/H1.4 chromatosome | electron microscopy | L | ZN | 1 (best 0.66) |
| 9DGG | ncPRC1RYBP bound to unmodified nucleosome | electron microscopy | L | ZN | 1 (best 0.61) |
| Q99496 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase RING2 (Q99496) | — | — | — |
Ligands
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.