UniProt Q99437
V-type proton ATPase 21 kDa proteolipid subunit (Q99437)
V-type proton ATPase 21 kDa proteolipid subunit (UniProt Q99437): 7 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q99437
- Protein
- V-type proton ATPase 21 kDa proteolipid subunit
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 7 · 2 records with a druggable one
Structures
8 records of Q99437 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6WLW | The Vo region of human V-ATPase in state 1 (focused refinement) | electron microscopy | 0 | WSS, PTY, CLR | 5 (best 0.76) |
| 6WLW | The vo region of human V-ATPase in state 1 (focused refinement) | electron microscopy | 0 | WSS, PTY, CLR | — |
| 6WM2 | Human V-ATPase in state 1 with sidk and ADP | electron microscopy | 0 | WSS, CLR, PTY | — |
| 6WM3 | Human V-ATPase in state 2 with sidk and ADP | electron microscopy | 0 | — | — |
| 6WM4 | Human V-ATPase in state 3 with SidK and ADP | electron microscopy | 0 | — | 2 (best 0.84) |
| 6WM4 | Human V-ATPase in state 3 with sidk and ADP | electron microscopy | 0 | — | — |
| 7UNF | CryoEM structure of a mEAK7 bound human V-ATPase complex | electron microscopy | 1 | NAG, POV | — |
| Q99437 | AlphaFold monomer V2.0 prediction for V-type proton ATPase 21 kda proteolipid subunit (Q99437) | predicted | A | — | — |
Ligands
- CLR · Cholesterol · in 3 records
- PTY · Phosphatidylethanolamine · in 3 records
- WSS · tri(methyl)-[2-[[(2~{R})-2-[(~{Z})-octadec-9-enoyl]oxy-3-[(~{E})-1-oxidanylideneoctadec-9-enoxy]propoxy]-oxidanyl-phosphoryl]oxyethyl]azanium · in 3 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 1 record
Experiment against prediction
- 6WLW chain 0 against the predicted model Q99437: TM-score 0.98, RMSD 0.82 Å
- 6WLW chain 0 against the predicted model Q99437: TM-score 0.98, RMSD 0.82 Å
- 6WM2 chain 0 against the predicted model Q99437: TM-score 0.98, RMSD 0.82 Å
- 6WM3 chain 0 against the predicted model Q99437: TM-score 0.98, RMSD 0.88 Å
- 6WM4 chain 0 against the predicted model Q99437: TM-score 0.98, RMSD 0.86 Å
- 6WM4 chain 0 against the predicted model Q99437: TM-score 0.98, RMSD 0.86 Å
- 7UNF chain 1 against the predicted model Q99437: TM-score 0.98, RMSD 0.87 Å
Elsewhere
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