UniProt Q99278
Mediator of RNA polymerase II transcription subunit 11 (Q99278)
Mediator of RNA polymerase II transcription subunit 11 (UniProt Q99278): 17 experimental structures and 1 predicted model on GenesisL1, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q99278
- Protein
- Mediator of RNA polymerase II transcription subunit 11
- Experimental structures
- 17
- Predicted models
- 1
- Pockets
- 7 · 3 records with a druggable one
Structures
18 records of Q99278 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3R84 | Structure of the Mediator head subcomplex Med11/22 | x-ray diffraction | A, C, E, G, I, K, M, O, Q, S, U, W | — | — |
| 3R84 | Structure of the mediator head subcomplex MED11/22 | x-ray diffraction | A, C, E, G, I, K, M, O, Q, S, U, W | — | — |
| 3RJ1 | Architecture of the Mediator Head module | x-ray diffraction | A, H, O | — | — |
| 3RJ1 | Architecture of the mediator head module | x-ray diffraction | A, H, O | — | — |
| 4GWP | Structure of the Mediator Head Module from S. cerevisiae | x-ray diffraction | A | — | — |
| 4GWP | Structure of the mediator head module from S. cerevisiae | x-ray diffraction | A | — | — |
| 4GWQ | Structure of the Mediator Head Module from S. cerevisiae in complex with the carboxy-terminal… | x-ray diffraction | A | — | — |
| 4GWQ | Structure of the mediator head module from S. cerevisiae in complex with the carboxy-terminal… | x-ray diffraction | A | — | — |
| 4H62 | Structure of the Saccharomyces cerevisiae Mediator subcomplex Med17C/Med11C/Med22C | x-ray diffraction | K | — | — |
| 4H62 | Structure of the saccharomyces cerevisiae mediator subcomplex MED17C/MED11C/MED22C | x-ray diffraction | K | — | — |
| 4V1O | Architecture of the RNA polymerase II-Mediator core transcription initiation complex | electron microscopy | V | — | — |
| 4V1O | Architecture of the RNA polymerase II-mediator core transcription initiation complex | electron microscopy | V | — | — |
| 5OQM | Structure of yeast transcription pre-initiation complex with tfiih and core mediator | electron microscopy | c | — | 1 (best 0.79) |
| 5OQM | Structure of yeast transcription pre-initiation complex with tfiih and core mediator | electron microscopy | c | — | — |
| 5SVA | Mediator-RNA polymerase II pre-initiation complex | electron microscopy | O | — | — |
| 7UIF | Mediator-PIC Early (Core B) | electron microscopy | k | — | 3 (best 0.83) |
| 7UIO | Mediator-PIC Early (Composite Model) | electron microscopy | Ak, Bk | — | 3 (best 0.87) |
| Q99278 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 11… | predicted | A | — | — |
Experiment against prediction
- 3R84 chain G against the predicted model Q99278: TM-score 0.99, RMSD 0.32 Å
- 3R84 chain G against the predicted model Q99278: TM-score 0.99, RMSD 0.32 Å
- 3R84 chain E against the predicted model Q99278: TM-score 0.99, RMSD 0.30 Å
- 3R84 chain E against the predicted model Q99278: TM-score 0.99, RMSD 0.30 Å
- 3R84 chain C against the predicted model Q99278: TM-score 0.98, RMSD 0.45 Å
- 3R84 chain C against the predicted model Q99278: TM-score 0.98, RMSD 0.45 Å
- 3R84 chain A against the predicted model Q99278: TM-score 0.98, RMSD 0.42 Å
- 3R84 chain A against the predicted model Q99278: TM-score 0.98, RMSD 0.42 Å
- 3R84 chain O against the predicted model Q99278: TM-score 0.98, RMSD 0.42 Å
- 3R84 chain O against the predicted model Q99278: TM-score 0.98, RMSD 0.42 Å
Elsewhere
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