UniProt Q98SW5
Smoothened (Q98SW5)
Smoothened (UniProt Q98SW5): 10 experimental structures on GenesisL1, 4 ligands bound, 28 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q98SW5
- Protein
- Smoothened
- Experimental structures
- 10
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 28 · 4 records with a druggable one
Structures
10 records of Q98SW5 in the MolNFT archive: 10 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5KZV | Crystal structure of the xenopus Smoothened cysteine-rich domain (CRD) in complex with… | x-ray diffraction | A | HCD | 2 (best 0.31) |
| 5KZV | Crystal structure of the xenopus smoothened cysteine-rich domain (crd) in complex with… | x-ray diffraction | A | HCD | 2 (best 0.31) |
| 5KZY | Crystal structure of the xenopus Smoothened cysteine-rich domain (CRD) in complex with cyclopamine | x-ray diffraction | A, B | CY8 | 4 (best 0.61) |
| 5KZY | Crystal structure of the xenopus smoothened cysteine-rich domain (crd) in complex with cyclopamine | x-ray diffraction | A, B | CY8 | 4 (best 0.61) |
| 5KZZ | Crystal structure of the xenopus Smoothened cysteine-rich domain (CRD) in its apo-form | x-ray diffraction | A | ZN | 1 (best 0.29) |
| 5KZZ | Crystal structure of the xenopus smoothened cysteine-rich domain (crd) in its apo-form | x-ray diffraction | A | ZN | 1 (best 0.29) |
| 6D32 | Crystal structure of Xenopus Smoothened in complex with cyclopamine | x-ray diffraction | A | CY8 | 7 (best 0.86) |
| 6D32 | Crystal structure of xenopus smoothened in complex with cyclopamine | x-ray diffraction | A | CY8 | — |
| 6D35 | Crystal structure of Xenopus Smoothened in complex with cholesterol | x-ray diffraction | A | CLR | 7 (best 0.85) |
| 6D35 | Crystal structure of xenopus smoothened in complex with cholesterol | x-ray diffraction | A | CLR | — |
Ligands
Experiment against prediction
- 6D35 chain A against the predicted model P0ABE7: TM-score 0.18, RMSD 1.77 Å
- 6D35 chain A against the predicted model P0ABE7: TM-score 0.18, RMSD 1.77 Å
- 6D32 chain A against the predicted model P0ABE7: TM-score 0.17, RMSD 1.78 Å
- 6D32 chain A against the predicted model P0ABE7: TM-score 0.17, RMSD 1.78 Å
Elsewhere
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