UniProt Q96RJ0
Soluble cytochrome b562,Trace amine-associated receptor 1 (Q96RJ0)
Soluble cytochrome b562,Trace amine-associated receptor 1 (UniProt Q96RJ0): 17 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 90 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q96RJ0
- Protein
- Soluble cytochrome b562,Trace amine-associated receptor 1
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 90 · 18 records with a druggable one
Structures
18 records of Q96RJ0 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8JLN | T1AM-bound hTAAR1-Gs protein complex | electron microscopy | R | UJF | 5 (best 0.82) |
| 8JLO | Ulotaront(SEP-363856)-bound hTAAR1-Gs protein complex | electron microscopy | R | UJL | 5 (best 0.80) |
| 8JLP | Ralmitaront(RO-6889450)-bound hTAAR1-Gs protein complex | electron microscopy | R | UJU | 4 (best 0.80) |
| 8JLQ | Fenoldopam-bound hTAAR1-Gs protein complex | electron microscopy | R | G3C | 5 (best 0.77) |
| 8JLR | A77636-bound hTAAR1-Gs protein complex | electron microscopy | R | VRK | 5 (best 0.77) |
| 8JSO | AMPH-bound hTAAR1-Gs protein complex | electron microscopy | R | 1WE | 4 (best 0.82) |
| 8UHB | Cryo-EM Structure of the Ro5256390-bound hTA1-Gs heterotrimer signaling complex | electron microscopy | A | WV8 | 7 (best 0.77) |
| 8W87 | Cryo-EM structure of the METH-TAAR1 complex | electron microscopy | R | B40 | 5 (best 0.75) |
| 8W88 | Cryo-EM structure of the SEP363856-bound TAAR1-Gs complex | electron microscopy | R | CLR, UJL | 7 (best 0.77) |
| 8W89 | Cryo-EM structure of the PEA-bound TAAR1-Gs complex | electron microscopy | R | PEA | 6 (best 0.77) |
| 8W8A | Cryo-EM structure of the RO5256390-TAAR1 complex | electron microscopy | R | T5U | 7 (best 0.76) |
| 8WC8 | Cryo-EM structure of the ZH8651-bound hTAAR1-Gs complex | electron microscopy | R | VMT | 4 (best 0.74) |
| 8WCA | Cryo-EM structure of the PEA-bound hTAAR1-Gs complex | electron microscopy | R | PEA | 3 (best 0.78) |
| 8ZSJ | Cryo-EM structure of the apo hTAAR1-Gs complex | electron microscopy | R | CLR | 4 (best 0.77) |
| 8ZSP | Cryo-EM structure of the LSD-bound hTAAR1-Gs complex | electron microscopy | R | 7LD | 4 (best 0.79) |
| 8ZSS | Cryo-EM structure of the RO5263397-bound hTAAR1-Gs complex | electron microscopy | R | A1D8X | 5 (best 0.77) |
| 9JKQ | Cryo-EM structure of the METH-bound hTAAR1-Gs complex | electron microscopy | R | B40 | 6 (best 0.81) |
| Q96RJ0 | AlphaFold monomer V2.0 prediction for trace amine-associated receptor 1 (Q96RJ0) | predicted | A | — | 4 (best 0.70) |
Ligands
- B40 · (2S)-N-methyl-1-phenylpropan-2-amine · in 2 records
- CLR · Cholesterol · in 2 records
- PEA · 2-phenylethylamine · in 2 records
- UJL · 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine · in 2 records
- 1WE · (2S)-1-phenylpropan-2-amine · in 1 record
- 7LD · (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide · in 1 record
- A1D8X · (4~{S})-4-(3-fluoranyl-2-methyl-phenyl)-1,3-oxazolidin-2-amine · in 1 record
- G3C · (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol · in 1 record
- T5U · (4S)-4-[(2S)-2-phenylbutyl]-1,3-oxazolidin-2-imine · in 1 record
- UJF · 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol · in 1 record
- UJU · 5-ethyl-4-methyl-~{N}-[4-[(2~{S})-morpholin-2-yl]phenyl]-1~{H}-pyrazole-3-carboxamide · in 1 record
- VMT · 2-(4-bromophenyl)ethanamine · in 1 record
- VRK · (1~{S},3~{R})-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1~{H}-isochromene-5,6-diol · in 1 record
- WV8 · (2R,4S)-4-[(2S)-2-phenylbutyl]-1,3-oxazolidin-2-amine · in 1 record
Experiment against prediction
- 8WC8 chain R against the predicted model Q96RJ0: TM-score 0.93, RMSD 1.99 Å
- 8W88 chain R against the predicted model Q96RJ0: TM-score 0.93, RMSD 2.11 Å
- 8ZSS chain R against the predicted model Q96RJ0: TM-score 0.93, RMSD 2.11 Å
- 8JLR chain R against the predicted model Q96RJ0: TM-score 0.93, RMSD 2.06 Å
- 8JSO chain R against the predicted model Q96RJ0: TM-score 0.93, RMSD 2.16 Å
- 8ZSP chain R against the predicted model Q96RJ0: TM-score 0.92, RMSD 2.20 Å
- 8W87 chain R against the predicted model Q96RJ0: TM-score 0.92, RMSD 2.28 Å
- 8W8A chain R against the predicted model Q96RJ0: TM-score 0.92, RMSD 2.28 Å
- 9JKQ chain R against the predicted model Q96RJ0: TM-score 0.92, RMSD 2.34 Å
- 8JLQ chain R against the predicted model Q96RJ0: TM-score 0.92, RMSD 2.21 Å
Elsewhere
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