UniProt Q96QK1
Vacuolar protein sorting-associated protein 35 (Q96QK1)
Vacuolar protein sorting-associated protein 35 (UniProt Q96QK1): 22 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 131 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q96QK1
- Protein
- Vacuolar protein sorting-associated protein 35
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 131 · 10 records with a druggable one
Structures
23 records of Q96QK1 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2R17 | Functional architecture of the retromer cargo-recognition complex | x-ray diffraction | C, D | — | 12 (best 0.75) |
| 2R17 | Functional architecture of the retromer cargo-recognition complex | x-ray diffraction | C, D | — | — |
| 5F0J | Structure of retromer VPS26-VPS35 subunits bound to SNX3 | x-ray diffraction | A | SO4 | — |
| 5F0J | Structure of retromer VPS26-VPS35 subunits bound to SNX3 | x-ray diffraction | A | — | — |
| 5F0K | Structure of VPS35 N terminal region | x-ray diffraction | A, B, C, D, E | SO4 | — |
| 5F0K | Structure of VPS35 N terminal region | x-ray diffraction | A, B, C, D, E | — | — |
| 5F0L | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 | x-ray diffraction | A | SO4 | 5 (best 0.67) |
| 5F0L | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 | x-ray diffraction | A | — | — |
| 5F0M | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 (SeMet labeled) | x-ray diffraction | A | SO4 | 5 (best 0.69) |
| 5F0M | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 (semet labeled) | x-ray diffraction | A | — | — |
| 5F0P | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1(L557M) (SeMet labeled) | x-ray diffraction | A | SO4 | 5 (best 0.69) |
| 5F0P | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1(L557M) (semet labeled) | x-ray diffraction | A | — | — |
| 5OSH | Structure of retromer VPS29-VPS35C subunits complexed with RidL N-terminal domain (1-236) | x-ray diffraction | B, E, H, K | — | 18 (best 0.78) |
| 5OSH | Structure of retromer VPS29-VPS35C subunits complexed with ridl N- terminal domain (1-236) | x-ray diffraction | B, E, H, K | — | — |
| 5OSI | Structure of retromer VPS29-VPS35C subunits complexed with ridl harpin loop (163-176) | x-ray diffraction | B, E, H, K | NA | — |
| 7BLN | VPS35/VPS29 arch of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteins | electron microscopy | A, C | — | 20 (best 0.87) |
| 7BLN | VPS35/VPS29 arch of metazoan membrane-assembled RETROMER:SNX3 complex modelled with human proteins | electron microscopy | A, C | — | — |
| 7BLO | VPS26 dimer region of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteins | electron microscopy | A, C | — | 15 (best 0.82) |
| 7BLO | VPS26 dimer region of metazoan membrane-assembled RETROMER:SNX3 complex modelled with human proteins | electron microscopy | A, C | — | — |
| 8R02 | Crystal structure of the retromer complex VPS29/VPS35 with the ligand bis-1,3-phenyl… | x-ray diffraction | C, D | XFZ | 13 (best 0.76) |
| 8R0J | Crystal structure of the retromer complex VPS29/VPS35 with the ligand bis-1,3-phenyl… | x-ray diffraction | C, D | XFZ | 14 (best 0.77) |
| 8RKS | Structure of VPS29-VPS35 bound to the LFa motif R21 of Fam21. | x-ray diffraction | B, D, F, H | — | 20 (best 0.74) |
| Q96QK1 | AlphaFold monomer V2.0 prediction for vacuolar protein sorting- associated protein 35 (Q96QK1) | predicted | A | — | 4 (best 0.44) |
Ligands
Experiment against prediction
- 8R0J chain C against the predicted model Q96QK1: TM-score 0.98, RMSD 0.81 Å
- 8RKS chain H against the predicted model Q96QK1: TM-score 0.98, RMSD 0.80 Å
- 5OSI chain H against the predicted model Q96QK1: TM-score 0.98, RMSD 0.85 Å
- 5OSI chain B against the predicted model Q96QK1: TM-score 0.98, RMSD 0.83 Å
- 8RKS chain D against the predicted model Q96QK1: TM-score 0.98, RMSD 0.84 Å
- 8RKS chain F against the predicted model Q96QK1: TM-score 0.98, RMSD 0.86 Å
- 8RKS chain B against the predicted model Q96QK1: TM-score 0.98, RMSD 0.87 Å
- 8R02 chain D against the predicted model Q96QK1: TM-score 0.98, RMSD 1.08 Å
- 2R17 chain C against the predicted model Q96QK1: TM-score 0.97, RMSD 1.07 Å
- 2R17 chain C against the predicted model Q96QK1: TM-score 0.97, RMSD 1.07 Å
Elsewhere
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