UniProt Q96E22
Dehydrodolichyl diphosphate synthase complex subunit NUS1 (Q96E22)
Dehydrodolichyl diphosphate synthase complex subunit NUS1 (UniProt Q96E22), EC 2.5.1.87: 11 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 30 pockets. Binding sites, druggability and experiment…
- UniProt
- Q96E22
- Protein
- Dehydrodolichyl diphosphate synthase complex subunit NUS1
- EC
- 2.5.1.87
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 30 · 5 records with a druggable one
Structures
12 records of Q96E22 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6W2L | Crystal structure of human dehydrodolichyl diphosphate synthase (NgBR/DHDDS) in complex with Mg and… | x-ray diffraction | B | MG, IPE | 5 (best 0.83) |
| 6W2L | Crystal structure of human dehydrodolichyl diphosphate synthase (NGBR/DHDDS) in complex with mg and… | x-ray diffraction | B | MG, IPE | — |
| 6Z1N | Structure of the human heterotetrameric cis-prenyltransferase complex | x-ray diffraction | B | PO4 | 7 (best 0.82) |
| 6Z1N | Structure of the human heterotetrameric cis-prenyltransferase complex | x-ray diffraction | B | PO4 | — |
| 7PAX | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium… | x-ray diffraction | B | IPE | — |
| 7PAY | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium and… | x-ray diffraction | B | SO4 | 5 (best 0.83) |
| 7PAY | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium and… | x-ray diffraction | B | SO4 | — |
| 7PB0 | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium… | x-ray diffraction | B | ISY, GGS | 5 (best 0.83) |
| 7PB0 | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium… | x-ray diffraction | B | ISY | — |
| 7PB1 | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium… | x-ray diffraction | B | MG, GRG, ISY | 5 (best 0.80) |
| 7PB1 | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium… | x-ray diffraction | B | ISY | — |
| Q96E22 | AlphaFold monomer V2.0 prediction for dehydrodolichyl diphosphate synthase complex subunit NUS1… | predicted | A | — | 3 (best 0.39) |
Ligands
- ISY · 3-methylbut-3-enylsulfanyl(phosphonooxy)phosphinic acid · in 4 records
- IPE · 3-methylbut-3-enyl trihydrogen diphosphate · in 3 records
- MG · Magnesium ion · in 3 records
- PO4 · Phosphate ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- GGS · Phosphonooxy-[(10E)-3,7,11,15-tetramethylhexadeca-2,6, 10,14-tetraenyl]sulfanyl-phosphinic acid · in 1 record
- GRG · Geranylgeranyl diphosphate · in 1 record
Experiment against prediction
- 7PB1 chain B against the predicted model Q96E22: TM-score 0.99, RMSD 0.51 Å
- 7PB1 chain B against the predicted model Q96E22: TM-score 0.99, RMSD 0.51 Å
- 6Z1N chain B against the predicted model Q96E22: TM-score 0.98, RMSD 0.90 Å
- 6Z1N chain B against the predicted model Q96E22: TM-score 0.98, RMSD 0.90 Å
- 7PB0 chain B against the predicted model Q96E22: TM-score 0.98, RMSD 0.91 Å
- 7PB0 chain B against the predicted model Q96E22: TM-score 0.98, RMSD 0.91 Å
- 6W2L chain B against the predicted model Q96E22: TM-score 0.97, RMSD 1.01 Å
- 6W2L chain B against the predicted model Q96E22: TM-score 0.97, RMSD 1.01 Å
- 7PAX chain B against the predicted model Q96E22: TM-score 0.97, RMSD 1.18 Å
- 7PAY chain B against the predicted model Q96E22: TM-score 0.97, RMSD 1.19 Å
Elsewhere
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