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Ligand · GGS

GGS · Phosphonooxy-[(10E)-3,7,11,15-tetramethylhexadeca-2,6, 10,14-tetraenyl]sulfanyl-phosphinic acid

GGS, Phosphonooxy-[(10E)-3,7,11,15-tetramethylhexadeca-2,6, 10,14-tetraenyl]sulfanyl-phosphinic acid (C20 H36 O6 P2 S, 466.5 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its…

Component
GGS
Formula
C20 H36 O6 P2 S
Class
ligand
Structures
8
PDB entries
4

Binding sites

GGS in 8 structures; the first of them:

  • 3AE0 · Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus… · GGS A1001 · binds HIS18, SER19, LYS20, SER21, PHE22, TYR41, ARG45, VAL133 and 16 more
  • 5GUE · Crystal structure of CotB2 (GGSPP/Mg2+-Bound Form) from Streptomyces melanosporofaciens · GGS A401 · binds VAL80, ASN103, THR106, PHE107, ASP110, PHE149, ARG177, ILE181 and 15 more
  • 7PAY · Structure of the human heterotetrameric cis-prenyltransferase complex in complex with… · GGS A403 · binds TRP3, MET33, ASP34, GLY35, ASN36, ARG37, ARG38, HIS51 and 15 more
  • 7PB0 · Structure of the human heterotetrameric cis-prenyltransferase complex in complex with… · GGS A402 · binds MET33, ASP34, GLY35, ASN36, ARG37, ARG38, HIS51, GLY54 and 15 more
  • 3AE0 · Crystal structure of the C(30) carotenoid dehydrosqualene synthase from staphylococcus… · GGS A1001 · binds HIS18, SER19, LYS20, SER21, PHE22, TYR41, ARG45, VAL133 and 16 more
  • 5GUE · Crystal structure of COTB2 (GGSPP/MG2+-bound form) from streptomyces melanosporofaciens · GGS A401 · binds VAL80, ASN103, THR106, PHE107, ASP110, PHE149, ARG177, ILE181 and 15 more
  • 7PAY · Structure of the human heterotetrameric cis-prenyltransferase complex in complex with… · GGS A403 · binds TRP3, MET33, ASP34, GLY35, ASN36, ARG37, ARG38, HIS51 and 15 more
  • 7PB0 · Structure of the human heterotetrameric cis-prenyltransferase complex in complex with… · GGS A402 · binds MET33, ASP34, GLY35, ASN36, ARG37, ARG38, HIS51, GLY54 and 15 more

Residues it binds most

ARG 20, LEU 20, PHE 20, ASN 20, VAL 20, ALA 12, GLY 16, TYR 20, ASP 16, TRP 10 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • ISY · 3-methylbut-3-enylsulfanyl(phosphonooxy)phosphinic acid
  • SO4 · Sulfate ion

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