UniProt Q93088
Betaine--homocysteine S-methyltransferase 1 (Q93088)
Betaine--homocysteine S-methyltransferase 1 (UniProt Q93088), EC 2.1.1.5: 7 experimental structures and 1 predicted model on GenesisL1, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q93088
- Protein
- Betaine--homocysteine S-methyltransferase 1
- EC
- 2.1.1.5
- Experimental structures
- 7
- Predicted models
- 1
- Pockets
- 18 · 1 record with a druggable one
Structures
8 records of Q93088 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1LT7 | Oxidized Homo sapiens betaine-homocysteine S-methyltransferase in complex with four Sm(III) ions | x-ray diffraction | A, B | — | — |
| 1LT7 | Oxidized homo sapiens betaine-homocysteine S-methyltransferase in complex with four SM(III) ions | x-ray diffraction | A, B | — | — |
| 1LT8 | Reduced Homo sapiens Betaine-Homocysteine S-Methyltransferase in Complex with… | x-ray diffraction | A, B | — | — |
| 1LT8 | Reduced homo sapiens betaine-homocysteine S-methyltransferase in complex with… | x-ray diffraction | A, B | — | — |
| 4M3P | Betaine-Homocysteine S-Methyltransferase from Homo sapiens complexed with Homocysteine | x-ray diffraction | A, B, C, D | — | — |
| 4M3P | Betaine-homocysteine S-methyltransferase from homo sapiens complexed with homocysteine | x-ray diffraction | A, B, C, D | — | — |
| 8D45 | Cryo-EM structure of human Kidney Betaine-Homocysteine Methyltransferase | electron microscopy | A, B, C, D | — | 18 (best 0.77) |
| Q93088 | AlphaFold monomer V2.0 prediction for betaine--homocysteine S-methyltransferase 1 (Q93088) | predicted | A | — | — |
Experiment against prediction
- 1LT8 chain B against the predicted model Q93088: TM-score 0.99, RMSD 0.64 Å
- 1LT8 chain B against the predicted model Q93088: TM-score 0.99, RMSD 0.64 Å
- 8D45 chain A against the predicted model Q93088: TM-score 0.99, RMSD 0.66 Å
- 8D45 chain C against the predicted model Q93088: TM-score 0.99, RMSD 0.66 Å
- 8D45 chain B against the predicted model Q93088: TM-score 0.99, RMSD 0.67 Å
- 8D45 chain D against the predicted model Q93088: TM-score 0.99, RMSD 0.67 Å
- 1LT8 chain A against the predicted model Q93088: TM-score 0.99, RMSD 0.73 Å
- 1LT8 chain A against the predicted model Q93088: TM-score 0.99, RMSD 0.73 Å
- 1LT7 chain A against the predicted model Q93088: TM-score 0.98, RMSD 0.82 Å
- 1LT7 chain A against the predicted model Q93088: TM-score 0.98, RMSD 0.82 Å
Elsewhere
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