UniProt Q92830
Histone acetyltransferase KAT2A (Q92830)
Histone acetyltransferase KAT2A (UniProt Q92830), EC 2.3.1.-, 2.3.1.48: 20 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 83 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q92830
- Protein
- Histone acetyltransferase KAT2A
- EC
- 2.3.1.-, 2.3.1.48
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 83 · 8 records with a druggable one
Structures
21 records of Q92830 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1F68 | NMR solution structure of the bromodomain from human GCN5 | solution nmr | A | — | — |
| 1F68 | NMR solution structure of the bromodomain from human GCN5 | solution nmr | A | — | — |
| 1Z4R | Human GCN5 Acetyltransferase | x-ray diffraction | A | — | — |
| 1Z4R | Human GCN5 acetyltransferase | x-ray diffraction | A | — | — |
| 3D7C | Crystal structure of the bromodomain of human GCN5, the general control of amino-acid synthesis… | x-ray diffraction | A, B | — | — |
| 3D7C | Crystal structure of the bromodomain of human GCN5, the general control of amino-acid synthesis… | x-ray diffraction | A, B | — | — |
| 5H84 | Human GCN5 bound to propionyl-CoA | x-ray diffraction | A | — | — |
| 5H86 | Human Gcn5 bound to butyryl-CoA | x-ray diffraction | A | BCO | 1 (best 0.59) |
| 5H86 | Human GCN5 bound to butyryl-CoA | x-ray diffraction | A | — | — |
| 5MLJ | Bromodomain of Human GCN5 with 4-bromo-2-methyl-5-(((3R,5R)-1-methyl-5-phenylpiperidin-3-yl)amino)py… | x-ray diffraction | A, B | 9ST | 3 (best 0.61) |
| 5MLJ | Bromodomain of human GCN5 with 4-bromo-2-methyl-5-(((3R,5R)-1-methyl… | x-ray diffraction | A, B | 9ST | — |
| 5TRL | Crystal structure of human GCN5 histone acetyltransferase domain | x-ray diffraction | C, D, E, F, B, A, G, H | SCA | 16 (best 0.77) |
| 5TRL | Crystal structure of human GCN5 histone acetyltransferase domain | x-ray diffraction | C, D, E, F, B, A, G, H | SCA | — |
| 5TRM | Crystal structure of human GCN5 histone acetyltransferase domain | x-ray diffraction | A, W, V, U, T, S, R, Q, P, O, N, M, L, K, J, F, C, B, D, E, G, H, I, X | — | — |
| 6J3P | Crystal structure of the human GCN5 bromodomain in complex with compound (R,R)-36n | x-ray diffraction | A, B | B8O | — |
| 6J3P | Crystal structure of the human GCN5 bromodomain in complex with compound (R,R)-36N | x-ray diffraction | A, B | B8O | — |
| 8E6O | Crystal structure of human GCN5 histone acetyltransferase domain | x-ray diffraction | A, B, C | UQ3 | 7 (best 0.64) |
| 8H65 | Crystal structure of human GCN5 histone acetyltransferase domain bound with butyryl-CoA | x-ray diffraction | C, D, E, F, B, A, G, H | BCO | 16 (best 0.73) |
| 8H6C | Crystal structure of human GCN5 histone acetyltransferase domain bound with malonyl-CoA | x-ray diffraction | C, D, E, F, B, A, G, H | MLC | 17 (best 0.78) |
| 8H6D | Crystal structure of human GCN5 histone acetyltransferase domain bound with glutaryl-CoA | x-ray diffraction | C, D, E, F, B, A, G, H | GRA | 15 (best 0.76) |
| Q92830 | AlphaFold monomer V2.0 prediction for histone acetyltransferase KAT2A (Q92830) | predicted | A | — | 8 (best 0.72) |
Ligands
- 9ST · 4-bromo-2-methyl-5-[[(3~{R},5~{R})-1-methyl-5-phenyl-piperidin-3-yl]amino]pyridazin-3-one · in 2 records
- B8O · 2-{[(3R,5R)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methylpiperidin-3-yl]amino}-3-methyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one · in 2 records
- BCO · Butyryl Coenzyme A · in 2 records
- SCA · Succinyl-coenzyme A · in 2 records
- GRA · glutaryl-coenzyme A · in 1 record
- MLC · Malonyl-coenzyme A · in 1 record
- UQ3 · S-{(3S,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5,10,14-tetraoxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (2R)-2-hydroxypropanethioate · in 1 record
Experiment against prediction
- 3D7C chain B against the predicted model Q92830: TM-score 0.99, RMSD 0.36 Å
- 3D7C chain B against the predicted model Q92830: TM-score 0.99, RMSD 0.36 Å
- 5MLJ chain B against the predicted model Q92830: TM-score 0.99, RMSD 0.37 Å
- 5MLJ chain B against the predicted model Q92830: TM-score 0.99, RMSD 0.37 Å
- 6J3P chain B against the predicted model Q92830: TM-score 0.99, RMSD 0.37 Å
- 6J3P chain B against the predicted model Q92830: TM-score 0.99, RMSD 0.37 Å
- 5TRM chain K against the predicted model Q92830: TM-score 0.99, RMSD 0.48 Å
- 5TRM chain M against the predicted model Q92830: TM-score 0.99, RMSD 0.56 Å
- 5TRM chain D against the predicted model Q92830: TM-score 0.98, RMSD 0.61 Å
- 5TRL chain G against the predicted model Q92830: TM-score 0.98, RMSD 0.61 Å
Elsewhere
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