UniProt Q92633
Lysophosphatidic acid receptor 1 (Q92633)
Lysophosphatidic acid receptor 1 (UniProt Q92633): 17 experimental structures on GenesisL1, 6 ligands bound, 25 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q92633
- Protein
- Lysophosphatidic acid receptor 1
- Experimental structures
- 17
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 25 · 8 records with a druggable one
Structures
17 records of Q92633 in the MolNFT archive: 17 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4Z34 | Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO9780307 | x-ray diffraction | A | ON7, 1WV | 3 (best 0.83) |
| 4Z34 | Crystal structure of human lysophosphatidic acid receptor 1 in complex with ONO9780307 | x-ray diffraction | A | — | — |
| 4Z35 | Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO-9910539 | x-ray diffraction | A | — | — |
| 4Z35 | Crystal structure of human lysophosphatidic acid receptor 1 in complex with ono-9910539 | x-ray diffraction | A | — | — |
| 4Z36 | Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO-3080573 | x-ray diffraction | A | ON3, 1WV | 4 (best 0.84) |
| 4Z36 | Crystal structure of human lysophosphatidic acid receptor 1 in complex with ono-3080573 | x-ray diffraction | A | — | — |
| 7TD0 | Lysophosphatidic acid receptor 1-gi complex bound to lpa | electron microscopy | R | NKP | — |
| 7TD1 | Lysophosphatidic acid receptor 1-gi complex bound to lpa, state a | electron microscopy | R | NKP | — |
| 7TD2 | Lysophosphatidic acid receptor 1-gi complex bound to lpa, state a | electron microscopy | R | NKP | — |
| 7YU3 | Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556 | electron microscopy | R | K6L | 2 (best 0.80) |
| 7YU6 | Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state2 | electron microscopy | R | K6L | 2 (best 0.80) |
| 7YU7 | Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state3 | electron microscopy | R | K6L | — |
| 7YU8 | Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state4 | electron microscopy | R | K6L | 3 (best 0.80) |
| 9IZG | Cryo-EM structure of LPA1-Gq complex with LPA | electron microscopy | R | NKP | 6 (best 0.82) |
| 9IZH | Cryo-EM structure of LPA1-G13 complex with LPA | electron microscopy | R | NKP | 3 (best 0.82) |
| 9J5V | Human Lysophosphatidic Acid Receptor 1-Gi complex bound to CpY | electron microscopy | R | A1L3Q | 2 (best 0.82) |
| Q92633 | AlphaFold monomer V2.0 prediction for lysophosphatidic acid receptor 1 (Q92633) | — | — | — |
Ligands
- NKP · (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate · in 5 records
- K6L · [(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate · in 4 records
- 1WV · (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate · in 2 records
- A1L3Q · CpY · in 1 record
- ON3 · 1-(4-{[(2S,3R)-2-(2,3-dihydro-1H-inden-2-yloxy)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]oxy}phenyl)cyclopropan ecarboxylic acid · in 1 record
- ON7 · {1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)-1 H-pyrrol-3-yl}acetic acid · in 1 record
Experiment against prediction
- 4Z35 chain A against the predicted model P0ABE7: TM-score 0.27, RMSD 2.27 Å
- 4Z35 chain A against the predicted model P0ABE7: TM-score 0.27, RMSD 2.27 Å
- 4Z34 chain A against the predicted model P0ABE7: TM-score 0.27, RMSD 2.26 Å
- 4Z34 chain A against the predicted model P0ABE7: TM-score 0.27, RMSD 2.26 Å
- 4Z36 chain A against the predicted model P0ABE7: TM-score 0.27, RMSD 2.37 Å
- 4Z36 chain A against the predicted model P0ABE7: TM-score 0.27, RMSD 2.37 Å
- 9IZG chain R against the predicted model P0ABE7: TM-score 0.27, RMSD 4.25 Å
- 9IZH chain R against the predicted model P0ABE7: TM-score 0.25, RMSD 4.57 Å
Elsewhere
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