UniProt Q8ZKF6
acetyl-CoA synthetase (Q8ZKF6)
acetyl-CoA synthetase (UniProt Q8ZKF6), EC 6.2.1.1: 17 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8ZKF6
- Protein
- acetyl-CoA synthetase
- EC
- 6.2.1.1
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 15 · 2 records with a druggable one
Structures
18 records of Q8ZKF6 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1PG3 | Acetyl CoA Synthetase, Acetylated on Lys609 | x-ray diffraction | A, B | MG, COA, PRX | 8 (best 0.86) |
| 1PG3 | Acetyl CoA synthetase, acetylated on LYS609 | x-ray diffraction | A, B | — | — |
| 1PG4 | Acetyl CoA Synthetase, Salmonella enterica | x-ray diffraction | A, B | CL, MG, COA, PRX | 7 (best 0.85) |
| 1PG4 | Acetyl CoA synthetase, salmonella enterica | x-ray diffraction | A, B | — | — |
| 2P20 | Acetyl-CoA Synthetase, R584A mutation | x-ray diffraction | A, B | — | — |
| 2P20 | Acetyl-CoA synthetase, R584A mutation | x-ray diffraction | A, B | — | — |
| 2P2B | Acetyl-CoA Synthetase, V386A mutation | x-ray diffraction | A, B | — | — |
| 2P2B | Acetyl-CoA synthetase, V386A mutation | x-ray diffraction | A, B | — | — |
| 2P2F | Acetyl-CoA Synthetase, wild-type with acetate, AMP, and CoA bound | x-ray diffraction | A, B | — | — |
| 2P2F | Acetyl-CoA synthetase, wild-type with acetate, AMP, and CoA bound | x-ray diffraction | A, B | — | — |
| 2P2J | Acetyl-CoA Synthetase, K609A mutation | x-ray diffraction | A, B | — | — |
| 2P2J | Acetyl-CoA synthetase, K609A mutation | x-ray diffraction | A, B | — | — |
| 2P2M | Acetyl-CoA Synthetase, R194A mutation | x-ray diffraction | A, B | — | — |
| 2P2M | Acetyl-CoA synthetase, R194A mutation | x-ray diffraction | A, B | — | — |
| 2P2Q | Acetyl-CoA Synthetase, R584E mutation | x-ray diffraction | A, B | — | — |
| 2P2Q | Acetyl-CoA synthetase, R584E mutation | x-ray diffraction | A, B | — | — |
| 5JRH | Crystal structure of salmonella enterica acetyl-CoA synthetase (acs) in complex with camp and… | x-ray diffraction | A, B | — | — |
| Q8ZKF6 | AlphaFold monomer V2.0 prediction for acetyl-coenzyme a synthetase (Q8ZKF6) | predicted | A | — | — |
Ligands
Experiment against prediction
- 2P2J chain A against the predicted model Q8ZKF6: TM-score 1.00, RMSD 0.33 Å
- 2P2J chain A against the predicted model Q8ZKF6: TM-score 1.00, RMSD 0.33 Å
- 2P2M chain A against the predicted model Q8ZKF6: TM-score 1.00, RMSD 0.36 Å
- 2P2M chain A against the predicted model Q8ZKF6: TM-score 1.00, RMSD 0.36 Å
- 2P2Q chain A against the predicted model Q8ZKF6: TM-score 1.00, RMSD 0.36 Å
- 2P2Q chain A against the predicted model Q8ZKF6: TM-score 1.00, RMSD 0.36 Å
- 2P20 chain A against the predicted model Q8ZKF6: TM-score 1.00, RMSD 0.38 Å
- 2P20 chain A against the predicted model Q8ZKF6: TM-score 1.00, RMSD 0.38 Å
- 2P2F chain A against the predicted model Q8ZKF6: TM-score 1.00, RMSD 0.40 Å
- 2P2F chain A against the predicted model Q8ZKF6: TM-score 1.00, RMSD 0.40 Å
Elsewhere
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