UniProt Q8WW43
Gamma-secretase subunit APH-1B (Q8WW43)
Gamma-secretase subunit APH-1B (UniProt Q8WW43): 2 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8WW43
- Protein
- Gamma-secretase subunit APH-1B
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 10 · 2 records with a druggable one
Structures
3 records of Q8WW43 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8OQY | Structure of apo form of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid… | electron microscopy | C | NAG, PC1 | 5 (best 0.68) |
| 8OQZ | Structure of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc in… | electron microscopy | C | NAG, PC1 | 5 (best 0.77) |
| Q8WW43 | AlphaFold monomer V2.0 prediction for gamma-secretase subunit aph-1B (Q8WW43) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8OQZ chain C against the predicted model Q8WW43: TM-score 0.97, RMSD 1.04 Å
- 8OQY chain C against the predicted model Q8WW43: TM-score 0.97, RMSD 1.17 Å
Elsewhere
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