UniProt Q8U0E4

DNA-directed RNA polymerase subunit Rpo3 (Q8U0E4)

DNA-directed RNA polymerase subunit Rpo3 (UniProt Q8U0E4), EC 2.7.7.6: 5 experimental structures and 1 predicted model on GenesisL1, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: Q8U0E4
Protein: DNA-directed RNA polymerase subunit Rpo3
EC: 2.7.7.6
Experimental structures: 5
Predicted models: 1
Pockets: 20 · 5 records with a druggable one

Structures

6 records of Q8U0E4 in the MolNFT archive: 5 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
8CRO	Cryo-EM structure of Pyrococcus furiosus transcription elongation complex	electron microscopy	D	—	4 (best 0.74)
8OKI	Cryo-EM structure of Pyrococcus furiosus transcription elongation complex bound to Spt4/5	electron microscopy	D	—	2 (best 0.79)
8ORQ	Cryo-EM structure of Pyrococcus furiosus apo form RNA polymerase open clamp conformation	electron microscopy	D	—	4 (best 0.75)
8P2I	Cryo-EM structure of Pyrococcus furiosus apo form RNA polymerase contracted clamp conformation with…	electron microscopy	D	—	4 (best 0.79)
8RBO	Cryo-EM structure of Pyrococcus furiosus apo form RNA polymerase contracted clamp conformation	electron microscopy	D	—	5 (best 0.77)
Q8U0E4	AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit D (Q8U0E4)	predicted	A	—	1 (best 0.29)

Experiment against prediction

8CRO chain D against the predicted model Q8U0E4: TM-score 0.97, RMSD 1.07 Å
8ORQ chain D against the predicted model Q8U0E4: TM-score 0.97, RMSD 1.13 Å
8P2I chain D against the predicted model Q8U0E4: TM-score 0.97, RMSD 1.13 Å
8RBO chain D against the predicted model Q8U0E4: TM-score 0.97, RMSD 1.15 Å
8OKI chain D against the predicted model Q8U0E4: TM-score 0.96, RMSD 1.28 Å

Elsewhere

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