UniProt Q8TDX5
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (Q8TDX5)
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (UniProt Q8TDX5), EC 4.1.1.45: 12 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 99 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8TDX5
- Protein
- 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
- EC
- 4.1.1.45
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 99 · 6 records with a druggable one
Structures
13 records of Q8TDX5 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2WM1 | The crystal structure of human alpha-amino-beta-carboxymuconate- epsilon-semialdehyde decarboxylase… | x-ray diffraction | A | ZN, 13P | 3 (best 0.61) |
| 2WM1 | The crystal structure of human alpha-amino-beta- carboxymuconate-epsilon-semialdehyde decarboxylase… | x-ray diffraction | A | — | — |
| 4IGM | 2.39 Angstrom X-ray Crystal structure of human ACMSD | x-ray diffraction | A, B, C, D, E, F | ZN | 20 (best 0.75) |
| 4IGM | 2.39 ångström X-ray crystal structure of human acmsd | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4IGN | 2.32 Angstrom X-ray Crystal structure of R47A mutant of human ACMSD | x-ray diffraction | A, B, C, D, E, F | ZN | 20 (best 0.76) |
| 4IGN | 2.32 ångström X-ray crystal structure of R47A mutant of human acmsd | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4IH3 | 2.5 Angstroms X-ray crystal structure of of human 2-amino-3-carboxymuconate-6-semialdehyde… | x-ray diffraction | A, B, C, D, E, F | ZN, PDC | 20 (best 0.76) |
| 4IH3 | 2.5 ångströms X-ray crystal structure of of human 2-amino-3- carboxymuconate-6-semialdehyde… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4OFC | 2.0 Angstroms X-ray crystal structure of human 2-amino-3-carboxymuconate-6-semialdehye decarboxylase | x-ray diffraction | A, B, C, D, E, F | ZN | 20 (best 0.76) |
| 4OFC | 2.0 ångströms X-ray crystal structure of human 2-amino-3- carboxymuconate-6-semialdehye… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 7PWY | Structure of human dimeric ACMSD in complex with the inhibitor TES-1025 | x-ray diffraction | A, B, C, D | ZN, 8EK, K | 16 (best 0.70) |
| 7PWY | Structure of human dimeric acmsd in complex with the inhibitor tes- 1025 | x-ray diffraction | A, B, C, D | ZN, 8EK, K | — |
| Q8TDX5 | AlphaFold monomer V2.0 prediction for 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase… | predicted | A | — | — |
Ligands
Experiment against prediction
- 7PWY chain C against the predicted model Q8TDX5: TM-score 1.00, RMSD 0.41 Å
- 7PWY chain C against the predicted model Q8TDX5: TM-score 1.00, RMSD 0.41 Å
- 7PWY chain B against the predicted model Q8TDX5: TM-score 1.00, RMSD 0.45 Å
- 7PWY chain B against the predicted model Q8TDX5: TM-score 1.00, RMSD 0.45 Å
- 7PWY chain A against the predicted model Q8TDX5: TM-score 0.99, RMSD 0.49 Å
- 7PWY chain A against the predicted model Q8TDX5: TM-score 0.99, RMSD 0.49 Å
- 4OFC chain E against the predicted model Q8TDX5: TM-score 0.99, RMSD 0.55 Å
- 4OFC chain E against the predicted model Q8TDX5: TM-score 0.99, RMSD 0.55 Å
- 4IGM chain E against the predicted model Q8TDX5: TM-score 0.99, RMSD 0.54 Å
- 4IGM chain E against the predicted model Q8TDX5: TM-score 0.99, RMSD 0.54 Å
Elsewhere
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