UniProt Q8TDS7
Soluble cytochrome b562,Mas-related G-protein coupled receptor member D (Q8TDS7)
Soluble cytochrome b562,Mas-related G-protein coupled receptor member D (UniProt Q8TDS7): 11 experimental structures on GenesisL1, 4 ligands bound, 24 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q8TDS7
- Protein
- Soluble cytochrome b562,Mas-related G-protein coupled receptor member D
- Experimental structures
- 11
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 24 · 6 records with a druggable one
Structures
11 records of Q8TDS7 in the MolNFT archive: 11 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7Y12 | Cryo-EM structure of MrgD-Gi complex with beta-alanine | electron microscopy | R | BAL, PLM | 4 (best 0.74) |
| 7Y12 | Cryo-EM structure of mrgd-gi complex with beta-alanine | electron microscopy | R | PLM | — |
| 7Y13 | Cryo-EM structure of apo-state MrgD-Gi complex (local) | electron microscopy | R | PLM | 3 (best 0.52) |
| 7Y13 | Cryo-EM structure of apo-state mrgd-gi complex (local) | electron microscopy | R | PLM | — |
| 7Y14 | Cryo-EM structure of MrgD-Gi complex with beta-alanine (local) | electron microscopy | R | BAL, PLM | 3 (best 0.54) |
| 7Y14 | Cryo-EM structure of mrgd-gi complex with beta-alanine (local) | electron microscopy | R | PLM | — |
| 7Y15 | Cryo-EM structure of apo-state MrgD-Gi complex | electron microscopy | R | PLM | 4 (best 0.74) |
| 7Y15 | Cryo-EM structure of apo-state mrgd-gi complex | electron microscopy | R | PLM | — |
| 9DQH | CryoEM structure of Gq-coupled MRGPRD with a new agonist EP-2825 | electron microscopy | A | A1BE2 | 6 (best 0.74) |
| 9DQJ | CryoEM structure of Gq-coupled MRGPRD with a new agonist EP-3945 | electron microscopy | A | A1BEQ | 4 (best 0.75) |
| Q8TDS7 | AlphaFold monomer V2.0 prediction for mas-related G-protein coupled receptor member D (Q8TDS7) | — | — | — |
Ligands
- PLM · Palmitic acid · in 8 records
- BAL · Beta-alanine · in 2 records
- A1BE2 · 2-({1-[2-(4-chlorophenyl)-2-methylpropanoyl]piperidin-4-yl}amino)-5,6,7,8-tetrahydroquinazolin-4(3H)-one · in 1 record
- A1BEQ · 2-({1-[1-(4-methoxyphenyl)cyclopropane-1-carbonyl]piperidin-4-yl}amino)quinazolin-4(3H)-one · in 1 record
Experiment against prediction
- 7Y13 chain R against the predicted model P0ABE7: TM-score 0.28, RMSD 4.23 Å
- 7Y13 chain R against the predicted model P0ABE7: TM-score 0.28, RMSD 4.23 Å
- 7Y14 chain R against the predicted model P0ABE7: TM-score 0.27, RMSD 4.48 Å
- 7Y14 chain R against the predicted model P0ABE7: TM-score 0.27, RMSD 4.48 Å
- 7Y12 chain R against the predicted model P0ABE7: TM-score 0.27, RMSD 3.99 Å
- 7Y12 chain R against the predicted model P0ABE7: TM-score 0.27, RMSD 3.99 Å
- 7Y15 chain R against the predicted model P0ABE7: TM-score 0.27, RMSD 4.49 Å
- 7Y15 chain R against the predicted model P0ABE7: TM-score 0.27, RMSD 4.49 Å
Elsewhere
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