UniProt Q8TCD5
5'(3')-deoxyribonucleotidase, cytosolic type (Q8TCD5)
5'(3')-deoxyribonucleotidase, cytosolic type (UniProt Q8TCD5), EC 3.1.3.-: 8 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8TCD5
- Protein
- 5'(3')-deoxyribonucleotidase, cytosolic type
- EC
- 3.1.3.-
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 10 · 3 records with a druggable one
Structures
9 records of Q8TCD5 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2I7D | Structure of Human cytosolic deoxyribonucleotidase in complex with deoxyuridine, AlF4 and Mg2+ | x-ray diffraction | A, B | — | — |
| 2I7D | Structure of human cytosolic deoxyribonucleotidase in complex with deoxyuridine, ALF4 and MG2+ | x-ray diffraction | A, B | — | — |
| 4L57 | High resolutin structure of human cytosolic 5'(3')-deoxyribonucleotidase | x-ray diffraction | A, B | — | — |
| 4L57 | High resolutin structure of human cytosolic 5'(3')- deoxyribonucleotidase | x-ray diffraction | A, B | — | — |
| 4YIH | Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor… | x-ray diffraction | A, B | MG, PO4, 2O2 | 4 (best 0.70) |
| 4YIH | Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor… | x-ray diffraction | A, B | — | — |
| 6G2N | Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor… | x-ray diffraction | A, B | MG, O84 | 3 (best 0.68) |
| 6G2N | Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor… | x-ray diffraction | A, B | MG, O84 | — |
| Q8TCD5 | AlphaFold monomer V2.0 prediction for 5'(3')-deoxyribonucleotidase, cytosolic type (Q8TCD5) | predicted | A | — | 3 (best 0.69) |
Ligands
- MG · Magnesium ion · in 3 records
- O84 · [(2~{R},4~{a}~{R},6~{R},7~{a}~{R})-6-[2,4-bis(oxidanylidene)-5-[(~{E})-3-phosphonoprop-1-enyl]pyrimidin-1-yl]-2-phenyl-4~{a},6,7,7~{a}-tetrahydro-4~{H}-furo[3,2-d][1,3]dioxin-2-yl]phosphonic acid · in 2 records
- 2O2 · 1-{2-deoxy-3,5-O-[phenyl(phosphono)methylidene]-beta-D-threo-pentofuranosyl}-5-[(E)-2-phosphonoethenyl]pyrimidine-2,4(1H,3H)-dione · in 1 record
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 4YIH chain B against the predicted model Q8TCD5: TM-score 0.99, RMSD 0.45 Å
- 4YIH chain B against the predicted model Q8TCD5: TM-score 0.99, RMSD 0.45 Å
- 4YIH chain A against the predicted model Q8TCD5: TM-score 0.99, RMSD 0.48 Å
- 4YIH chain A against the predicted model Q8TCD5: TM-score 0.99, RMSD 0.48 Å
- 4L57 chain A against the predicted model Q8TCD5: TM-score 0.99, RMSD 0.49 Å
- 4L57 chain A against the predicted model Q8TCD5: TM-score 0.99, RMSD 0.49 Å
- 6G2N chain B against the predicted model Q8TCD5: TM-score 0.99, RMSD 0.49 Å
- 2I7D chain B against the predicted model Q8TCD5: TM-score 0.99, RMSD 0.55 Å
- 2I7D chain B against the predicted model Q8TCD5: TM-score 0.99, RMSD 0.55 Å
- 6G2N chain A against the predicted model Q8TCD5: TM-score 0.99, RMSD 0.59 Å
Elsewhere
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