UniProt Q8NRC3
2-oxoglutarate dehydrogenase E1/E2 component (Q8NRC3)
2-oxoglutarate dehydrogenase E1/E2 component (UniProt Q8NRC3), EC 1.2.4.2, 2.3.1.61: 6 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 125 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8NRC3
- Protein
- 2-oxoglutarate dehydrogenase E1/E2 component
- EC
- 1.2.4.2, 2.3.1.61
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 125 · 7 records with a druggable one
Structures
7 records of Q8NRC3 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8P5S | Crystal structure of the homohexameric 2-oxoglutarate dehydrogenase OdhA from Corynebacterium… | x-ray diffraction | A | COA, ACO, TPP, MG | 9 (best 0.78) |
| 8P5T | Single particle cryo-EM structure of the homohexameric 2-oxoglutarate dehydrogenase OdhA from… | electron microscopy | A, B, C, D, E, F | MG, ACO, TPP | 20 (best 0.90) |
| 8P5U | Single particle cryo-EM structure of homohexameric 2-oxoglutarate dehydrogenase OdhA from… | electron microscopy | A, B, C, D, E, F | MG, COA, ACO, TPP | 20 (best 0.90) |
| 8P5V | Single particle cryo-EM structure of homohexameric 2-oxoglutarate dehydrogenase OdhA from… | electron microscopy | A, B, C, D, E, F | MG, ACO, TPP, SCA | 20 (best 0.88) |
| 8P5W | Single particle cryo-EM structure of homohexameric 2-oxoglutarate dehydrogenase OdhA from… | electron microscopy | A, B, C, D, E, F | MG, ACO, QSP | 20 (best 0.90) |
| 8P5X | Single particle cryo-EM structure of the complex between Corynebacterium glutamicum homohexameric… | electron microscopy | A, B, C, D, E, F | TPP, MG | 20 (best 0.89) |
| Q8NRC3 | AlphaFold monomer V2.0 prediction for 2-oxoglutarate dehydrogenase E1/E2 component (Q8NRC3) | predicted | A | — | 16 (best 0.74) |
Ligands
- MG · Magnesium ion · in 6 records
- ACO · Acetyl coenzyme *A · in 5 records
- TPP · Thiamine diphosphate · in 5 records
- COA · Coenzyme A · in 2 records
- QSP · (4~{S})-4-[(2~{R})-3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl(phosphonooxy) phosphoryl]oxyethyl]-2~{H}-1,3-thiazol-2-yl]-4-oxidanyl-4-phosphono-butanoic acid · in 1 record
- SCA · Succinyl-coenzyme A · in 1 record
Experiment against prediction
- 8P5S chain A against the predicted model Q8NRC3: TM-score 0.98, RMSD 1.54 Å
- 8P5V chain A against the predicted model Q8NRC3: TM-score 0.95, RMSD 2.55 Å
- 8P5V chain E against the predicted model Q8NRC3: TM-score 0.95, RMSD 2.57 Å
- 8P5V chain C against the predicted model Q8NRC3: TM-score 0.95, RMSD 2.57 Å
- 8P5V chain D against the predicted model Q8NRC3: TM-score 0.95, RMSD 2.64 Å
- 8P5V chain F against the predicted model Q8NRC3: TM-score 0.95, RMSD 2.68 Å
- 8P5V chain B against the predicted model Q8NRC3: TM-score 0.95, RMSD 2.68 Å
- 8P5T chain F against the predicted model Q8NRC3: TM-score 0.93, RMSD 3.14 Å
- 8P5T chain E against the predicted model Q8NRC3: TM-score 0.93, RMSD 3.15 Å
- 8P5T chain D against the predicted model Q8NRC3: TM-score 0.93, RMSD 3.15 Å
Elsewhere
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