UniProt Q8NNK2
Cytochrome c oxidase subunit 2 (Q8NNK2)
Cytochrome c oxidase subunit 2 (UniProt Q8NNK2), EC 7.1.1.9: 6 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q8NNK2
- Protein
- Cytochrome c oxidase subunit 2
- EC
- 7.1.1.9
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 20 · 3 records with a druggable one
Structures
7 records of Q8NNK2 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7Q21 | III2-IV2 respiratory supercomplex from Corynebacterium glutamicum | electron microscopy | G, g | CU, 7PH, MG, HAS, HEC | 7 (best 0.90) |
| 7Q21 | III2-IV2 respiratory supercomplex from corynebacterium glutamicum | electron microscopy | G, g | CU, 7PH, MG, HAS | — |
| 7QHM | Cytochrome bcc-aa3 supercomplex (respiratory supercomplex III2/IV2) from Corynebacterium glutamicum… | electron microscopy | E, R | HEC, HAS, MN, 3PE, CUA, DGA | 7 (best 0.90) |
| 7QHM | Cytochrome bcc-AA3 supercomplex (respiratory supercomplex III2/IV2) from corynebacterium glutamicum… | electron microscopy | E, R | HEC, HAS, MN, 3PE, CUA, DGA | — |
| 7QHO | Cytochrome bcc-aa3 supercomplex (respiratory supercomplex III2/IV2) from Corynebacterium glutamicum… | electron microscopy | E, R | HEC, HAS, 3PE, MN, CUA, DGA | 6 (best 0.89) |
| 7QHO | Cytochrome bcc-AA3 supercomplex (respiratory supercomplex III2/IV2) from corynebacterium glutamicum… | electron microscopy | E, R | HEC, HAS, 3PE, MN, CUA, DGA | — |
| Q8NNK2 | AlphaFold monomer V2.0 prediction for cytochrome C oxidase subunit 2 (Q8NNK2) | predicted | A | — | — |
Ligands
- HAS · Heme-as · in 6 records
- HEC · Heme C · in 5 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 4 records
- CUA · Dinuclear copper ion · in 4 records
- DGA · Diacyl glycerol · in 4 records
- IX7 · [(2~{R})-3-[[(1~{S},2~{R},3~{R},4~{S},5~{S},6~{R})-2-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hexadecanoyloxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-6-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3,4, 5-tris(oxidanyl)cyclohexyl]oxy-oxidanyl-phosphoryl]oxy-2-undecanoyloxy-propyl] (10~{S})-10-methylhenicosanoate · in 4 records
- MN · Manganese (II) ion · in 4 records
- 7PH · (1R)-2-(dodecanoyloxy)-1-[(phosphonooxy)methyl]ethyl tetradecanoate · in 2 records
- CU · Copper (II) ion · in 2 records
- MG · Magnesium ion · in 2 records
Experiment against prediction
- 7QHM chain R against the predicted model Q8NNK2: TM-score 0.98, RMSD 1.10 Å
- 7QHM chain R against the predicted model Q8NNK2: TM-score 0.98, RMSD 1.10 Å
- 7QHM chain E against the predicted model Q8NNK2: TM-score 0.97, RMSD 1.12 Å
- 7QHM chain E against the predicted model Q8NNK2: TM-score 0.97, RMSD 1.12 Å
- 7Q21 chain G against the predicted model Q8NNK2: TM-score 0.97, RMSD 1.13 Å
- 7Q21 chain G against the predicted model Q8NNK2: TM-score 0.97, RMSD 1.13 Å
- 7Q21 chain g against the predicted model Q8NNK2: TM-score 0.97, RMSD 1.16 Å
- 7Q21 chain g against the predicted model Q8NNK2: TM-score 0.97, RMSD 1.16 Å
- 7QHO chain R against the predicted model Q8NNK2: TM-score 0.97, RMSD 1.19 Å
- 7QHO chain R against the predicted model Q8NNK2: TM-score 0.97, RMSD 1.19 Å
Elsewhere
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