UniProt Q8NI22
Multiple coagulation factor deficiency protein 2 (Q8NI22)
Multiple coagulation factor deficiency protein 2 (UniProt Q8NI22): 26 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 79 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8NI22
- Protein
- Multiple coagulation factor deficiency protein 2
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 79 · 6 records with a druggable one
Structures
27 records of Q8NI22 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2VRG | Structure of human MCFD2 | solution nmr | A | — | — |
| 2VRG | Structure of human MCFD2 | solution nmr | A | — | — |
| 3A4U | Crystal structure of MCFD2 in complex with carbohydrate recognition domain of ERGIC-53 | x-ray diffraction | B | — | — |
| 3A4U | Crystal structure of MCFD2 in complex with carbohydrate recognition domain of ergic-53 | x-ray diffraction | B | — | — |
| 3LCP | Crystal structure of the carbohydrate recognition domain of LMAN1 in complex with MCFD2 | x-ray diffraction | C, D | — | — |
| 3LCP | Crystal structure of the carbohydrate recognition domain of LMAN1 in complex with MCFD2 | x-ray diffraction | C, D | — | — |
| 3WHT | Crystal structure of ERGIC-53/MCFD2, Calcium-free form | x-ray diffraction | B | — | — |
| 3WHT | Crystal structure of ergic-53/MCFD2, calcium-free form | x-ray diffraction | B | — | — |
| 3WHU | Crystal structure of ERGIC-53/MCFD2, Calcium/Man2-bound form | x-ray diffraction | B | — | — |
| 3WHU | Crystal structure of ergic-53/MCFD2, CALCIUM/MAN2-bound form | x-ray diffraction | B | — | — |
| 3WNX | Crystal structure of ERGIC-53/MCFD2, Calcium/Man3-bound form | x-ray diffraction | B | — | — |
| 3WNX | Crystal structure of ergic-53/MCFD2, CALCIUM/MAN3-bound form | x-ray diffraction | B | — | — |
| 4YGB | Crystal structure of ERGIC-53/MCFD2, monoclinic calcium-free form | x-ray diffraction | B, D | — | — |
| 4YGB | Crystal structure of ergic-53/MCFD2, monoclinic calcium-free form | x-ray diffraction | B, D | — | — |
| 4YGC | Crystal structure of ERGIC-53/MCFD2, monoclinic calcium-bound form 1 | x-ray diffraction | B, D, F, H | — | — |
| 4YGC | Crystal structure of ergic-53/MCFD2, monoclinic calcium-bound form 1 | x-ray diffraction | B, D, F, H | — | — |
| 4YGD | Crystal structure of ERGIC-53/MCFD2, monoclinic calcium-bound form 2 | x-ray diffraction | B, D, F, H | — | — |
| 4YGD | Crystal structure of ergic-53/MCFD2, monoclinic calcium-bound form 2 | x-ray diffraction | B, D, F, H | — | — |
| 4YGE | Crystal structure of ERGIC-53/MCFD2, trigonal calcium-bound form 2 | x-ray diffraction | B, D, F | — | — |
| 4YGE | Crystal structure of ergic-53/MCFD2, trigonal calcium-bound form 2 | x-ray diffraction | B, D, F | — | — |
| 8JP4 | Cryo-EM structure of the head region of full-length ERGIC-53 with MCFD2 (form A) | electron microscopy | C, D, G, H | CA, ZN | 13 (best 0.77) |
| 8JP6 | Cryo-EM structures of the head region of full-length ERGIC-53 with MCFD2 (Substate A) | electron microscopy | C, D, G, H | CA, ZN | 14 (best 0.60) |
| 8JP7 | Cryo-EM structure of the head region of full-length ERGIC-53 with MCFD2 (Substate B) | electron microscopy | C, D, G, H | CA, ZN | 12 (best 0.76) |
| 8JP8 | Cryo-EM structure of the head region of full-length ERGIC-53 with MCFD2 (Substate C) | electron microscopy | C, D, G, H | CA, ZN | 15 (best 0.56) |
| 8JP9 | Cryo-EM structure of the head region of full-length ERGIC-53 with MCFD2 (Substate D) | electron microscopy | C, D, G, H | CA, ZN | 15 (best 0.76) |
| 8JPG | Cryo-EM structure of full-length ERGIC-53 with MCFD2 | electron microscopy | C, G, D, H | CA, ZN | 10 (best 0.79) |
| Q8NI22 | AlphaFold monomer V2.0 prediction for multiple coagulation factor deficiency protein 2 (Q8NI22) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4YGC chain B against the predicted model Q8NI22: TM-score 0.98, RMSD 0.44 Å
- 4YGC chain B against the predicted model Q8NI22: TM-score 0.98, RMSD 0.44 Å
- 4YGC chain F against the predicted model Q8NI22: TM-score 0.98, RMSD 0.38 Å
- 4YGC chain F against the predicted model Q8NI22: TM-score 0.98, RMSD 0.38 Å
- 4YGE chain F against the predicted model Q8NI22: TM-score 0.98, RMSD 0.45 Å
- 4YGE chain F against the predicted model Q8NI22: TM-score 0.98, RMSD 0.45 Å
- 4YGE chain B against the predicted model Q8NI22: TM-score 0.98, RMSD 0.46 Å
- 4YGE chain B against the predicted model Q8NI22: TM-score 0.98, RMSD 0.46 Å
- 4YGC chain D against the predicted model Q8NI22: TM-score 0.97, RMSD 0.95 Å
- 4YGC chain D against the predicted model Q8NI22: TM-score 0.97, RMSD 0.95 Å
Elsewhere
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