UniProt Q8NFU1
Bestrophin-2 (Q8NFU1)
Bestrophin-2 (UniProt Q8NFU1): 8 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 60 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8NFU1
- Protein
- Bestrophin-2
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 60 · 3 records with a druggable one
Structures
9 records of Q8NFU1 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8D1E | hBest2 1uM Ca2+ (Ca2+-bound) closed state | electron microscopy | D, E, C, A, B | CA, MC3, DU0, CL | 20 (best 0.76) |
| 8D1E | HBEST2 1UM CA2+ (CA2+-bound) closed state | electron microscopy | D, E, C, A, B | CA, MC3, DU0, CL | — |
| 8D1F | hBest2 5mM Ca2+ (Ca2+-bound) closed state | electron microscopy | C, E, A, D, B | CA, DU0, MC3, CL | 20 (best 0.75) |
| 8D1F | HBEST2 5MM CA2+ (CA2+-bound) closed state | electron microscopy | C, E, A, D, B | CA, DU0, MC3, CL | — |
| 8D1G | hBest2 Ca2+-bound open state | electron microscopy | A, B, E, C, D | CA, DU0, MC3, CL | 20 (best 0.71) |
| 8D1G | HBEST2 CA2+-bound open state | electron microscopy | A, B, E, C, D | CA, DU0, MC3 | — |
| 8D1H | hBest2 Ca2+-unbound closed state | electron microscopy | E, B, A, C, D | MC3, DU0, CL | — |
| 8D1H | HBEST2 CA2+-unbound closed state | electron microscopy | E, B, A, C, D | MC3, DU0, CL | — |
| Q8NFU1 | AlphaFold monomer V2.0 prediction for bestrophin-2 (Q8NFU1) | predicted | A | — | — |
Ligands
- DU0 · 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R}, 9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4, 8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol · in 8 records
- MC3 · 1,2-dimyristoyl-rac-glycero-3-phosphocholine · in 8 records
- CL · Chloride ion · in 7 records
- CA · Calcium ion · in 6 records
Experiment against prediction
- 8D1E chain C against the predicted model Q8NFU1: TM-score 0.99, RMSD 0.77 Å
- 8D1E chain C against the predicted model Q8NFU1: TM-score 0.99, RMSD 0.77 Å
- 8D1E chain A against the predicted model Q8NFU1: TM-score 0.99, RMSD 0.77 Å
- 8D1E chain D against the predicted model Q8NFU1: TM-score 0.99, RMSD 0.77 Å
- 8D1E chain A against the predicted model Q8NFU1: TM-score 0.99, RMSD 0.77 Å
- 8D1E chain D against the predicted model Q8NFU1: TM-score 0.99, RMSD 0.77 Å
- 8D1E chain B against the predicted model Q8NFU1: TM-score 0.99, RMSD 0.77 Å
- 8D1E chain B against the predicted model Q8NFU1: TM-score 0.99, RMSD 0.77 Å
- 8D1E chain E against the predicted model Q8NFU1: TM-score 0.99, RMSD 0.77 Å
- 8D1E chain E against the predicted model Q8NFU1: TM-score 0.99, RMSD 0.77 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.