UniProt Q8NBR6
Ubiquitin carboxyl-terminal hydrolase MINDY-2 (Q8NBR6)
Ubiquitin carboxyl-terminal hydrolase MINDY-2 (UniProt Q8NBR6), EC 3.4.19.12: 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 94 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8NBR6
- Protein
- Ubiquitin carboxyl-terminal hydrolase MINDY-2
- EC
- 3.4.19.12
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 94 · 6 records with a druggable one
Structures
7 records of Q8NBR6 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6Z49 | Crystal structure of deubiquitinase Mindy2 | x-ray diffraction | A, B, C, D | CL | 14 (best 0.71) |
| 6Z49 | Crystal structure of deubiquitinase MINDY2 | x-ray diffraction | A, B, C, D | CL | 14 (best 0.71) |
| 6Z7V | Crystal structure of Mindy2 (C266A) in complex with Lys48 linked di-ubiquitin (K48-Ub2) | x-ray diffraction | A, B | K | 17 (best 0.75) |
| 6Z7V | Crystal structure of MINDY2 (C266A) in complex with LYS48 linked di- ubiquitin (K48-UB2) | x-ray diffraction | A, B | K | 17 (best 0.75) |
| 7NPI | Crystal structure of Mindy2 (C266A) in complex with Lys48-linked penta-ubiquitin (K48-Ub5) | x-ray diffraction | A, G, M, S, Y, e, k | CL, NA | 16 (best 0.79) |
| 7NPI | Crystal structure of MINDY2 (C266A) in complex with LYS48-linked penta-ubiquitin (K48-UB5) | x-ray diffraction | A, G, M, S, Y, e, k | CL, NA | 16 (best 0.79) |
| Q8NBR6 | AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase mindy-2 (Q8NBR6) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6Z7V chain B against the predicted model Q8NBR6: TM-score 0.99, RMSD 0.55 Å
- 6Z7V chain B against the predicted model Q8NBR6: TM-score 0.99, RMSD 0.55 Å
- 6Z7V chain A against the predicted model Q8NBR6: TM-score 0.99, RMSD 0.56 Å
- 6Z7V chain A against the predicted model Q8NBR6: TM-score 0.99, RMSD 0.56 Å
- 7NPI chain G against the predicted model Q8NBR6: TM-score 0.99, RMSD 0.78 Å
- 7NPI chain A against the predicted model Q8NBR6: TM-score 0.98, RMSD 0.80 Å
- 7NPI chain A against the predicted model Q8NBR6: TM-score 0.98, RMSD 0.80 Å
- 7NPI chain Y against the predicted model Q8NBR6: TM-score 0.98, RMSD 0.84 Å
- 7NPI chain k against the predicted model Q8NBR6: TM-score 0.98, RMSD 0.87 Å
- 7NPI chain S against the predicted model Q8NBR6: TM-score 0.98, RMSD 0.87 Å
Elsewhere
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