UniProt Q8N8U2
Chromodomain Y-like protein 2 (Q8N8U2)
Chromodomain Y-like protein 2 (UniProt Q8N8U2): 15 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 30 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8N8U2
- Protein
- Chromodomain Y-like protein 2
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 30 · 2 records with a druggable one
Structures
16 records of Q8N8U2 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2MJ8 | Solution structure of CDYL2 chromodomain | solution nmr | A | — | — |
| 2MJ8 | Solution structure of CDYL2 chromodomain | solution nmr | A | — | — |
| 4HAE | Crystal structure of the CDYL2-chromodomain | x-ray diffraction | A | — | — |
| 4HAE | Crystal structure of the CDYL2-chromodomain | x-ray diffraction | A | — | — |
| 5JJZ | Chromo domain of human Chromodomain Protein, Y-Like 2 | x-ray diffraction | A | — | — |
| 5JJZ | Chromo domain of human chromodomain protein, Y-like 2 | x-ray diffraction | A | — | — |
| 6V2D | Crystal Structure of chromodomain of CDYL2 in complex with inhibitor UNC3866 | x-ray diffraction | A, C, E, G, I, K | UNX | 6 (best 0.46) |
| 6V2D | Crystal structure of chromodomain of CDYL2 in complex with inhibitor UNC3866 | x-ray diffraction | A, C, E, G, I, K | 5R0, 5R5, UNX | — |
| 6V2H | Crystal structure of CDYL2 in complex with H3tK27me3 | x-ray diffraction | A, C, E, G, I, K | NI, UNX | 2 (best 0.78) |
| 6V2H | Crystal structure of CDYL2 in complex with H3TK27ME3 | x-ray diffraction | A, C, E, G, I, K | ACE, NI, UNX | — |
| 6V3N | Crystal structure of CDYL2 in complex with H3K27me3 | x-ray diffraction | A, B | UNX | 2 (best 0.38) |
| 6V3N | Crystal structure of CDYL2 in complex with H3K27ME3 | x-ray diffraction | A, B | NH2, UNX | — |
| 6V8W | CDYL2 chromodomain in complex with a synthetic peptide | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z | UNX | 13 (best 0.68) |
| 7SLW | Complex structure of CDYL2 with an antagonist | x-ray diffraction | A, B, C, D, E, F | 5R0, UNX | — |
| 8SP6 | Complex structure of CDYL2 with an antagonist | x-ray diffraction | A, B, C, D, E, F | UNX, I9A | 7 (best 0.47) |
| Q8N8U2 | AlphaFold monomer V2.0 prediction for chromodomain Y-like protein 2 (Q8N8U2) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7SLW chain B against the predicted model Q8N8U2: TM-score 0.86, RMSD 1.30 Å
- 7SLW chain C against the predicted model Q8N8U2: TM-score 0.85, RMSD 1.35 Å
- 8SP6 chain F against the predicted model Q8N8U2: TM-score 0.85, RMSD 1.67 Å
- 6V2D chain I against the predicted model Q8N8U2: TM-score 0.84, RMSD 1.36 Å
- 6V2D chain I against the predicted model Q8N8U2: TM-score 0.84, RMSD 1.36 Å
- 6V2D chain K against the predicted model Q8N8U2: TM-score 0.84, RMSD 1.59 Å
- 6V2D chain K against the predicted model Q8N8U2: TM-score 0.84, RMSD 1.59 Å
- 7SLW chain D against the predicted model Q8N8U2: TM-score 0.84, RMSD 1.58 Å
- 8SP6 chain D against the predicted model Q8N8U2: TM-score 0.84, RMSD 1.60 Å
- 7SLW chain E against the predicted model Q8N8U2: TM-score 0.84, RMSD 1.62 Å
Elsewhere
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