UniProt Q8N697
Solute carrier family 15 member 4 (Q8N697)
Solute carrier family 15 member 4 (UniProt Q8N697): 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 79 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8N697
- Protein
- Solute carrier family 15 member 4
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 79 · 9 records with a druggable one
Structures
9 records of Q8N697 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8JZS | Outward-facing SLC15A4 dimer | electron microscopy | B, A | NAG, CLR | 14 (best 0.80) |
| 8JZX | SLC15A4 inhibitor complex | electron microscopy | A, B | NAG, CLR, Q09 | 10 (best 0.81) |
| 8P6A | cryo-EM structure of human SLC15A4 in outward-open state | electron microscopy | A | — | 5 (best 0.78) |
| 8QSK | Cryo-EM structure of human SLC15A4 dimer in outward open state in MSP1D1 nanodisc | electron microscopy | A, C | Y01, NAG, PGT | 12 (best 0.82) |
| 8QSL | Cryo-EM structure of human SLC15A4 dimer in outward open state in LMNG | electron microscopy | A, C | Y01, NAG, PGT | 12 (best 0.82) |
| 8QSM | Cryo-EM structure of human SLC15A4 monomer in outward open state in LMNG | electron microscopy | A | — | 5 (best 0.82) |
| 8QSN | Cryo-EM structure of human SLC15A4 monomer in outward open state in PMAL C8 | electron microscopy | A | — | 5 (best 0.82) |
| 8WX3 | Cryo-EM structure of human SLC15A4 (outward-facing open) | electron microscopy | A, B | — | 12 (best 0.83) |
| Q8N697 | AlphaFold monomer V2.0 prediction for solute carrier family 15 member 4 (Q8N697) | predicted | A | — | 4 (best 0.76) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- CLR · Cholesterol · in 2 records
- PGT · (1S)-2-{[{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · in 2 records
- Y01 · Cholesterol hemisuccinate · in 2 records
- Q09 · 2-(4-ethoxyphenyl)-N-[3-[(2R)-2-methylpiperidin-1-yl]propyl]quinoline-4-carboxamide · in 1 record
Experiment against prediction
- 8P6A chain A against the predicted model Q8N697: TM-score 0.76, RMSD 4.68 Å
- 8WX3 chain A against the predicted model Q8N697: TM-score 0.76, RMSD 4.72 Å
- 8WX3 chain B against the predicted model Q8N697: TM-score 0.76, RMSD 4.76 Å
- 8QSM chain A against the predicted model Q8N697: TM-score 0.76, RMSD 4.65 Å
- 8QSN chain A against the predicted model Q8N697: TM-score 0.76, RMSD 4.65 Å
- 8JZS chain B against the predicted model Q8N697: TM-score 0.76, RMSD 4.56 Å
- 8JZS chain A against the predicted model Q8N697: TM-score 0.76, RMSD 4.56 Å
- 8QSK chain A against the predicted model Q8N697: TM-score 0.74, RMSD 4.72 Å
- 8QSK chain C against the predicted model Q8N697: TM-score 0.74, RMSD 4.73 Å
- 8QSL chain A against the predicted model Q8N697: TM-score 0.74, RMSD 4.74 Å
Elsewhere
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