UniProt Q8IZD2
Histone-lysine N-methyltransferase 2E (Q8IZD2)
Histone-lysine N-methyltransferase 2E (UniProt Q8IZD2), EC 2.1.1.43: 6 experimental structures and 1 predicted model on GenesisL1, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8IZD2
- Protein
- Histone-lysine N-methyltransferase 2E
- EC
- 2.1.1.43
- Experimental structures
- 6
- Predicted models
- 1
- Pockets
- 10 · 1 record with a druggable one
Structures
7 records of Q8IZD2 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LV9 | Solution NMR structure of the PHD domain of human MLL5, Northeast structural genomics consortium… | solution nmr | A | — | — |
| 2LV9 | Solution NMR structure of the phd domain of human MLL5, northeast structural genomics consortium… | solution nmr | A | — | — |
| 4L58 | Crystal structure of the MLL5 PHD finger in complex with H3K4me3 | x-ray diffraction | A | — | — |
| 4L58 | Crystal structure of the MLL5 phd finger in complex with H3K4ME3 | x-ray diffraction | A | — | — |
| 5HT6 | Crystal structure of the SET domain of the human MLL5 methyltransferase | x-ray diffraction | A, B | — | 5 (best 0.45) |
| 5HT6 | Crystal structure of the set domain of the human MLL5 methyltransferase | x-ray diffraction | A, B | — | — |
| Q8IZD2 | AlphaFold monomer V2.0 prediction for inactive histone-lysine N-methyltransferase 2E (Q8IZD2) | predicted | A | — | 5 (best 0.69) |
Experiment against prediction
- 4L58 chain A against the predicted model Q8IZD2: TM-score 0.96, RMSD 0.64 Å
- 4L58 chain A against the predicted model Q8IZD2: TM-score 0.96, RMSD 0.64 Å
- 5HT6 chain B against the predicted model Q8IZD2: TM-score 0.94, RMSD 1.57 Å
- 5HT6 chain B against the predicted model Q8IZD2: TM-score 0.94, RMSD 1.57 Å
- 5HT6 chain A against the predicted model Q8IZD2: TM-score 0.90, RMSD 1.82 Å
- 5HT6 chain A against the predicted model Q8IZD2: TM-score 0.90, RMSD 1.82 Å
- 2LV9 chain A against the predicted model Q8IZD2: TM-score 0.74, RMSD 2.23 Å
- 2LV9 chain A against the predicted model Q8IZD2: TM-score 0.74, RMSD 2.23 Å
Elsewhere
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