UniProt Q8IYW5
E3 ubiquitin-protein ligase RNF168 (Q8IYW5)
E3 ubiquitin-protein ligase RNF168 (UniProt Q8IYW5), EC 2.3.2.23, 2.3.2.24: 44 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 81 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8IYW5
- Protein
- E3 ubiquitin-protein ligase RNF168
- EC
- 2.3.2.23, 2.3.2.24, 2.3.2.27
- Experimental structures
- 44
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 81 · 31 records with a druggable one
Structures
45 records of Q8IYW5 in the MolNFT archive: 44 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3L11 | Crystal Structure of the Ring Domain of RNF168 | x-ray diffraction | A | — | — |
| 3L11 | Crystal structure of the ring domain of RNF168 | x-ray diffraction | A | — | — |
| 4GB0 | Crystal Structure of the RING domain of RNF168 | x-ray diffraction | A | — | — |
| 4GB0 | Crystal structure of the ring domain of RNF168 | x-ray diffraction | A | — | — |
| 5XIS | Crystal structure of RNF168 UDM1 in complex with Lys63-linked diubiquitin, form I | x-ray diffraction | A, D | XYZ | 4 (best 0.37) |
| 5XIS | Crystal structure of RNF168 UDM1 in complex with LYS63-linked diubiquitin, form I | x-ray diffraction | A, D | XYZ | — |
| 5XIT | Crystal structure of RNF168 UDM1 in complex with Lys63-linked diubiquitin, form II | x-ray diffraction | E, A | PR | 5 (best 0.47) |
| 5XIT | Crystal structure of RNF168 UDM1 in complex with LYS63-linked diubiquitin, form II | x-ray diffraction | E, A | — | — |
| 5XIU | Crystal structure of RNF168 UDM2 in complex with Lys63-linked diubiquitin | x-ray diffraction | A | — | — |
| 5XIU | Crystal structure of RNF168 UDM2 in complex with LYS63-linked diubiquitin | x-ray diffraction | A | — | — |
| 5YDK | Crystal structure of RNF168 UDM1 in complex with Lys63-linked diubiquitin, tetrameric form | x-ray diffraction | A, G, F, L | — | 14 (best 0.75) |
| 5YDK | Crystal structure of RNF168 UDM1 in complex with LYS63-linked diubiquitin, tetrameric form | x-ray diffraction | A, G, F, L | — | — |
| 8SMW | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub… | electron microscopy | K | ZN | 1 (best 0.78) |
| 8SMX | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub… | electron microscopy | K | ZN | 2 (best 0.67) |
| 8SMY | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub… | electron microscopy | K | ZN | 1 (best 0.80) |
| 8SMZ | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub… | electron microscopy | K | ZN | 1 (best 0.78) |
| 8SN0 | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub… | electron microscopy | K | ZN | 1 (best 0.81) |
| 8SN1 | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub… | electron microscopy | K | ZN | 1 (best 0.78) |
| 8SN2 | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c (UbcH5c… | electron microscopy | K | ZN | 1 (best 0.82) |
| 8SN3 | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub… | electron microscopy | K | ZN | 1 (best 0.81) |
| 8SN4 | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub… | electron microscopy | K | ZN | 1 (best 0.75) |
| 8SN5 | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub… | electron microscopy | K | ZN | 1 (best 0.77) |
| 8SN6 | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub… | electron microscopy | K | ZN | 2 (best 0.75) |
| 8SN7 | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub… | electron microscopy | K | ZN | 1 (best 0.76) |
| 8SN8 | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub… | electron microscopy | K | ZN | 1 (best 0.75) |
| 8SN9 | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c with… | electron microscopy | K | ZN | 1 (best 0.77) |
| 8SNA | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c with… | electron microscopy | K | ZN | 2 (best 0.77) |
| 8TXV | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex… | electron microscopy | K | — | 1 (best 0.70) |
| 8TXW | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex… | electron microscopy | K | — | 1 (best 0.73) |
| 8TXX | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex… | electron microscopy | K | — | 1 (best 0.78) |
| 8U13 | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A lysine 15 in… | electron microscopy | K | ZN | 1 (best 0.63) |
| 8U14 | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A lysine 15 in… | electron microscopy | K | ZN | 1 (best 0.78) |
| 8UPF | Cryo-EM structure of the human nucleosome core particle in complex with RNF168-UbcH5c | electron microscopy | K | ZN | 1 (best 0.76) |
| 8UQ8 | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 2-residue linker | x-ray diffraction | A, a | CL, ZN, NA | 6 (best 0.73) |
| 8UQ9 | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 4-residue linker | x-ray diffraction | A, a | CL, ZN, NA | 7 (best 0.74) |
| 8UQA | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 12-residue linker | x-ray diffraction | K | NA, ZN, CL | 3 (best 0.52) |
| 8UQB | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization… | x-ray diffraction | A | ZN, CL | 3 (best 0.53) |
| 8UQC | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization… | x-ray diffraction | A | ZN | 4 (best 0.55) |
| 8UQD | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (condition 2.… | x-ray diffraction | B | — | 2 (best 0.46) |
| 8UQE | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 26-residue linker (RING not… | x-ray diffraction | B | — | 3 (best 0.44) |
| 8X7I | Cryo-EM structures of RNF168/UbcH5c-Ub in complex with H2AK13Ub nucleosomes determined by… | electron microscopy | L | ZN | 1 (best 0.68) |
| 8X7J | Cryo-EM structures of RNF168/UbcH5c-Ub/nucleosomes complex determined by activity-based chemical… | electron microscopy | L | ZN | 1 (best 0.76) |
| 8X7K | Cryo-EM structures of RNF168/UbcH5c-Ub in complex with H2AK13Ub nucleosomes determined by… | electron microscopy | L | ZN | 2 (best 0.69) |
| 9IPU | cryo-EM structure of the RNF168(1-193)/UbcH5c-Ub ubiquitylation module bound to H1.0-K63-Ub3… | electron microscopy | L | ZN | 1 (best 0.74) |
| Q8IYW5 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase RNF168 (Q8IYW5) | predicted | A | — | 1 (best 0.31) |
Ligands
Experiment against prediction
- 8UQA chain K against the predicted model P61077: TM-score 0.34, RMSD 0.43 Å
- 8UQC chain A against the predicted model P61077: TM-score 0.35, RMSD 0.43 Å
- 8UQ8 chain A against the predicted model P61077: TM-score 0.34, RMSD 0.44 Å
- 8UQ8 chain a against the predicted model P61077: TM-score 0.35, RMSD 0.44 Å
- 8UQ9 chain a against the predicted model P61077: TM-score 0.34, RMSD 0.44 Å
- 8UQD chain B against the predicted model P61077: TM-score 0.44, RMSD 0.46 Å
- 8UQB chain A against the predicted model P61077: TM-score 0.36, RMSD 0.47 Å
- 8UQ9 chain A against the predicted model P61077: TM-score 0.34, RMSD 0.48 Å
- 8UQE chain B against the predicted model P61077: TM-score 0.44, RMSD 0.47 Å
- 4GB0 chain A against the predicted model Q8IYW5: TM-score 0.99, RMSD 0.37 Å
Elsewhere
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