UniProt Q8IYT8
Serine/threonine-protein kinase ULK2 (Q8IYT8)
Serine/threonine-protein kinase ULK2 (UniProt Q8IYT8), EC 2.7.11.1: 8 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 46 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8IYT8
- Protein
- Serine/threonine-protein kinase ULK2
- EC
- 2.7.11.1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 46 · 5 records with a druggable one
Structures
9 records of Q8IYT8 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6QAT | Crystal structure of ULK2 in complexed with hesperadin | x-ray diffraction | A, B, C, D | FE7 | 10 (best 0.74) |
| 6QAT | Crystal structure of ULK2 in complexed with hesperadin | x-ray diffraction | A, B, C, D | FE7 | — |
| 6QAU | Crystal structure of ULK2 in complexed with MRT67307 | x-ray diffraction | A, B, C | 1FV, CL | 6 (best 0.83) |
| 6QAU | Crystal structure of ULK2 in complexed with MRT67307 | x-ray diffraction | A, B, C | 1FV, CL | — |
| 6QAV | Crystal structure of ULK2 in complexed with MRT68921 | x-ray diffraction | A, B, C, D | HVH, NA | 5 (best 0.89) |
| 6QAV | Crystal structure of ULK2 in complexed with MRT68921 | x-ray diffraction | A, B, C, D | HVH, NA | — |
| 6YID | Crystal structure of ULK2 in complex with SBI-0206965 | x-ray diffraction | A, B, C, D | EDJ | 11 (best 0.81) |
| 6YID | Crystal structure of ULK2 in complex with sbi-0206965 | x-ray diffraction | A, B, C, D | EDJ | — |
| Q8IYT8 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase ULK2 (Q8IYT8) | predicted | A | — | 14 (best 0.71) |
Ligands
- 1FV · N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl) phenyl]amino}pyrimidin-4-yl) amino]propyl}cyclobutanecarboxamide · in 2 records
- CL · Chloride ion · in 2 records
- EDJ · 2-({5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}oxy)-N-methylbenzene-1-carboximidic acid · in 2 records
- FE7 · N-{(3Z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl) methyl]phenyl}amino)methylidene]-2,3-dihydro-1H-indol-5-yl}ethanesulfonamide · in 2 records
- HVH · ~{N}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{H}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide · in 2 records
- NA · Sodium ion · in 2 records
Experiment against prediction
- 6QAT chain D against the predicted model Q8IYT8: TM-score 0.93, RMSD 1.55 Å
- 6QAT chain D against the predicted model Q8IYT8: TM-score 0.93, RMSD 1.55 Å
- 6QAU chain B against the predicted model Q8IYT8: TM-score 0.93, RMSD 1.74 Å
- 6QAU chain B against the predicted model Q8IYT8: TM-score 0.93, RMSD 1.74 Å
- 6QAT chain C against the predicted model Q8IYT8: TM-score 0.92, RMSD 1.87 Å
- 6QAT chain C against the predicted model Q8IYT8: TM-score 0.92, RMSD 1.87 Å
- 6QAU chain C against the predicted model Q8IYT8: TM-score 0.92, RMSD 1.64 Å
- 6QAU chain C against the predicted model Q8IYT8: TM-score 0.92, RMSD 1.64 Å
- 6YID chain D against the predicted model Q8IYT8: TM-score 0.92, RMSD 1.92 Å
- 6YID chain D against the predicted model Q8IYT8: TM-score 0.92, RMSD 1.92 Å
Elsewhere
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