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Ligand · EDJ

EDJ · 2-({5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}oxy)-N-methylbenzene-1-carboximidic acid

EDJ, 2-({5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}oxy)-N-methylbenzene-1-carboximidic acid (C21 H21 Br N4 O5, 489.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB entries). Every binding site with…

Component
EDJ
Formula
C21 H21 Br N4 O5
Class
ligand
Structures
2
PDB entries
2

Binding sites

EDJ in 2 structures; the first of them:

  • 6BX6 · AMP-activated protein kinase (ampk) inhibition by sbi-0206965: alpha 2 kinase domain… · EDJ A301 · binds LEU22, GLY23, ALA43, GLU94, TYR95, VAL96, SER97, GLY99 and 2 more
  • 6YID · Crystal structure of ULK2 in complex with sbi-0206965 · EDJ A301 · binds VAL15, GLY16, HIS17, VAL23, ALA37, LYS39, MET85, GLU86 and 7 more

Residues it binds most

GLY 5, VAL 5, ALA 5, ASN 4, LEU 5, GLU 5, TYR 5, CYS 4, GLN 4, LYS 4 (residue and the binding sites it lines).

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