UniProt Q8IVT5
Chimera protein of BRS domain of BRAF and CC-SAM domain of KSR1,Serine/threonine-protein kinase B-raf (Q8IVT5)
Chimera protein of BRS domain of BRAF and CC-SAM domain of KSR1,Serine/threonine-protein kinase B-raf (UniProt Q8IVT5), EC 2.7.11.1: 11 experimental structures on GenesisL1, 3 ligands bound, 13 pockets. Binding sites, pockets…
- UniProt
- Q8IVT5
- Protein
- Chimera protein of BRS domain of BRAF and CC-SAM domain of…
- EC
- 2.7.11.1
- Experimental structures
- 11
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 13 · 3 records with a druggable one
Structures
11 records of Q8IVT5 in the MolNFT archive: 11 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5VYK | Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1 | x-ray diffraction | A, C | — | 5 (best 0.80) |
| 5VYK | Crystal structure of the brs domain of braf in complex with the cc-SAM domain of KSR1 | x-ray diffraction | A, C | — | — |
| 7JUW | Crystal structure of KSR1:MEK1 in complex with AMP-pnp | x-ray diffraction | B | ANP, MG | — |
| 7JUX | Crystal structure of KSR1:MEK1 in complex with AMP-pnp, and allosteric MEK inhibitor trametinib | x-ray diffraction | A | ANP, MG | — |
| 7JUY | Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib | x-ray diffraction | B | ANP, MG | 4 (best 0.81) |
| 7JUY | Crystal structure of KSR1:MEK1 in complex with AMP-pnp, and allosteric MEK inhibitor cobimetinib | x-ray diffraction | B | ANP, MG | — |
| 7JUZ | Crystal structure of KSR1:MEK1 in complex with AMP-pnp, and allosteric MEK inhibitor selumetinib | x-ray diffraction | A | ANP | — |
| 7JV0 | Crystal structure of KSR1:MEK1 in complex with AMP-pnp, and allosteric MEK inhibitor PD0325901 | x-ray diffraction | A | ANP, MG | — |
| 7JV1 | Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1 | x-ray diffraction | D | ANP, MG, VKG | 4 (best 0.83) |
| 7JV1 | Crystal structure of KSR1:MEK1 in complex with AMP-pnp, and allosteric MEK inhibitor aps-9-95-1 | x-ray diffraction | D | ANP, MG, VKG | — |
| Q8IVT5 | AlphaFold monomer V2.0 prediction for kinase suppressor of RAS 1 (Q8IVT5) | — | — | — |
Ligands
Experiment against prediction
- 5VYK chain A against the predicted model P15056: TM-score 0.42, RMSD 4.78 Å
- 5VYK chain A against the predicted model P15056: TM-score 0.42, RMSD 4.78 Å
- 5VYK chain C against the predicted model P15056: TM-score 0.42, RMSD 4.79 Å
- 5VYK chain C against the predicted model P15056: TM-score 0.42, RMSD 4.79 Å
Elsewhere
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