UniProt Q8IVH4
Methylmalonic aciduria type A protein, mitochondrial (Q8IVH4)
Methylmalonic aciduria type A protein, mitochondrial (UniProt Q8IVH4), EC 3.6.-.-: 3 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 22 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8IVH4
- Protein
- Methylmalonic aciduria type A protein, mitochondrial
- EC
- 3.6.-.-
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 22 · 2 records with a druggable one
Structures
4 records of Q8IVH4 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2WWW | Crystal Structure of Methylmalonic Acidemia Type A Protein | x-ray diffraction | A, B, C, D | — | — |
| 2WWW | Crystal structure of methylmalonic acidemia type a protein | x-ray diffraction | A, B, C, D | — | — |
| 8GJU | Crystal structure of human methylmalonyl-CoA mutase (MMUT) in complex with methylmalonic acidemia… | x-ray diffraction | D, F, A, B | GDP, MG | 16 (best 0.87) |
| Q8IVH4 | AlphaFold monomer V2.0 prediction for methylmalonic aciduria type a protein, mitochondrial (Q8IVH4) | predicted | A | — | 6 (best 0.65) |
Ligands
Experiment against prediction
- 2WWW chain B against the predicted model Q8IVH4: TM-score 0.95, RMSD 1.54 Å
- 2WWW chain B against the predicted model Q8IVH4: TM-score 0.95, RMSD 1.54 Å
- 2WWW chain D against the predicted model Q8IVH4: TM-score 0.94, RMSD 1.79 Å
- 2WWW chain D against the predicted model Q8IVH4: TM-score 0.94, RMSD 1.79 Å
- 8GJU chain B against the predicted model Q8IVH4: TM-score 0.93, RMSD 2.16 Å
- 8GJU chain A against the predicted model Q8IVH4: TM-score 0.93, RMSD 2.16 Å
- 8GJU chain D against the predicted model Q8IVH4: TM-score 0.93, RMSD 2.32 Å
- 8GJU chain F against the predicted model Q8IVH4: TM-score 0.93, RMSD 2.34 Å
- 2WWW chain A against the predicted model Q8IVH4: TM-score 0.92, RMSD 1.90 Å
- 2WWW chain A against the predicted model Q8IVH4: TM-score 0.92, RMSD 1.90 Å
Elsewhere
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