UniProt Q8IU60
DCP2 (NUDT20) (Q8IU60)
DCP2 (NUDT20) (UniProt Q8IU60), EC 3.6.1.62: 46 experimental structures and 1 predicted model on GenesisL1, 30 ligands bound, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8IU60
- Protein
- DCP2 (NUDT20)
- EC
- 3.6.1.62
- Experimental structures
- 46
- Predicted models
- 1
- Ligands
- 30
- Pockets
- 1 · 1 record with a druggable one
Structures
47 records of Q8IU60 in the MolNFT archive: 46 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5MP0 | Human M7GPPPN-mRNA hydrolase (DCP2, NUDT20) catalytic domain | x-ray diffraction | D | — | — |
| 5QOH | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with XST00000847B | x-ray diffraction | A | JGD | — |
| 5QOI | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with FMOPL000213A | x-ray diffraction | A | LD4 | — |
| 5QOJ | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with FMOCR000171B | x-ray diffraction | A | JG4 | — |
| 5QOK | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with FMOPL000294A | x-ray diffraction | A | AWS | — |
| 5QOL | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with FMOPL000435A | x-ray diffraction | A | JGP | — |
| 5QOM | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with FMOPL000576A | x-ray diffraction | A | LDV | — |
| 5QON | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with FMOPL000446a | x-ray diffraction | A | LDS | — |
| 5QON | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with FMOPL000446A | x-ray diffraction | A | LDS | — |
| 5QOO | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with FMOPL000144a | x-ray diffraction | A | LDJ | — |
| 5QOO | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with FMOPL000144A | x-ray diffraction | A | LDJ | — |
| 5QOP | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with NUOOA000023a | x-ray diffraction | A | LDD | — |
| 5QOP | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with NUOOA000023A | x-ray diffraction | A | LDD | — |
| 5QOQ | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z2895259680 | x-ray diffraction | A | LD7 | — |
| 5QOR | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with Z1203490773 | x-ray diffraction | A | LEY | — |
| 5QOR | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z1203490773 | x-ray diffraction | A | LEY | — |
| 5QOS | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z1187701032 | x-ray diffraction | A | LES | — |
| 5QOT | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with Z1592710382 | x-ray diffraction | A | LEJ | — |
| 5QOT | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z1592710382 | x-ray diffraction | A | LEJ | — |
| 5QOU | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z296300542 | x-ray diffraction | A | LE7 | — |
| 5QOV | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z1699011516 | x-ray diffraction | A | LE4 | — |
| 5QOW | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z2895259675 | x-ray diffraction | A | LFP | — |
| 5QOX | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z2212124043 | x-ray diffraction | A | LFM | — |
| 5QOY | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with yw-fy-378 | x-ray diffraction | A | LFJ | — |
| 5QOZ | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with PB1787571279 | x-ray diffraction | A | LFG | — |
| 5QP0 | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z454376544 | x-ray diffraction | A | LF4 | — |
| 5QP1 | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with Z1190363272 | x-ray diffraction | A | LJ7 | — |
| 5QP1 | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z1190363272 | x-ray diffraction | A | LJ7 | — |
| 5QP2 | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z1170065264 | x-ray diffraction | A | LHS | — |
| 5QP3 | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z1494850193 | x-ray diffraction | A | LHM | — |
| 5QP4 | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with Z450133538 | x-ray diffraction | A | LH7 | 1 (best 0.55) |
| 5QP4 | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z450133538 | x-ray diffraction | A | LH7 | — |
| 5QP5 | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z2895259681 | x-ray diffraction | A | LFY | — |
| 5QP6 | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with Z1662802141 | x-ray diffraction | A | LJM | — |
| 5QP6 | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z1662802141 | x-ray diffraction | A | LJM | — |
| 5QP7 | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with PB1230873739 | x-ray diffraction | A | LJJ | — |
| 5QP7 | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with PB1230873739 | x-ray diffraction | A | LJJ | — |
| 5QP8 | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with PB1787571279 | x-ray diffraction | A | LFG | — |
| 5QP9 | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with Z100435060 | x-ray diffraction | A | LJD | — |
| 5QP9 | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with Z100435060 | x-ray diffraction | A | LJD | — |
| 5QPA | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with FMOPL000449a | x-ray diffraction | A | JH1 | — |
| 5QPA | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with FMOPL000449A | x-ray diffraction | A | JH1 | — |
| 5QPB | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with FMOPL000701a | x-ray diffraction | A | LJA | — |
| 5QPB | Pandda analysis group deposition -- crystal structure of DCP2 (NUDT20) in complex with FMOPL000701A | x-ray diffraction | A | LJA | — |
| 5QPC | Crystal Structure of DCP2 (NUDT20) after initial refinement with no ligand modelled (structure $n) | x-ray diffraction | A | — | — |
| 5QPC | Crystal structure of DCP2 (NUDT20) after initial refinement with no ligand modelled (structure $N) | x-ray diffraction | A | — | — |
| Q8IU60 | AlphaFold monomer V2.0 prediction for M7GPPPN-mRNA hydrolase (Q8IU60) | predicted | A | — | — |
Ligands
- JH1 · 1-ethyl-N-[(4-fluorophenyl)methyl]-1H-pyrazole-4-carboxamide · in 2 records
- LDD · (azepan-1-yl)(4-methoxyphenyl)methanone · in 2 records
- LDJ · 2-methyl-N-{5-[(2S)-oxolan-2-yl]-1,3,4-thiadiazol-2(3H)-ylidene}propanamide · in 2 records
- LDS · N-(4-ethoxyphenyl)pyrazine-2-carboxamide · in 2 records
- LEJ · 1-(difluoromethyl)-N-[(4-fluorophenyl)methyl]-1H-pyrazole-3-carboxamide · in 2 records
- LEY · N-[(4-fluorophenyl)methyl]-2-(propan-2-yl)-1H-imidazole-5-carboxamide · in 2 records
- LFG · N-cycloheptyl-5-cyclopropyl-1,3,4-oxadiazol-2-amine · in 2 records
- LH7 · 1-[(3S)-1,1-dioxo-1lambda~6~-thiolan-3-yl]-N-[(4-fluorophenyl)methyl]-5-methyl-1H-pyrazole-4-carboxamide · in 2 records
- LJ7 · N-[(4-fluorophenyl)methyl]-1-(propan-2-yl)-1H-pyrazole-3-carboxamide · in 2 records
- LJA · N-[3-(carbamoylamino)phenyl]acetamide · in 2 records
- LJD · N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazole-4-carboxamide · in 2 records
- LJJ · N-cycloheptyl-5-methyl-1,3,4-oxadiazol-2-amine · in 2 records
- LJM · 5-ethyl-N-[(4-fluorophenyl)methyl]-1,3-thiazole-2-carboxamide · in 2 records
- AWS · 8-[(dimethylamino)methyl]-4-methyl-7-oxidanyl-chromen-2-one · in 1 record
- JG4 · 2-(thiophen-2-yl)-1H-imidazole · in 1 record
- JGD · N,N-dimethylpyridin-4-amine · in 1 record
- JGP · (azepan-1-yl)(2H-1,3-benzodioxol-5-yl)methanone · in 1 record
- LD4 · N-cycloheptylpyrimidin-2-amine · in 1 record
- LD7 · 3-ethyl-N-[(4-fluorophenyl)methyl]-1,2,4-oxadiazole-5-carboxamide · in 1 record
- LDV · 3-[(4-methylpiperidin-1-yl)methyl]-1H-indole · in 1 record
- LE4 · [2-(cycloheptylamino)pyrimidin-4-yl]methanol · in 1 record
- LE7 · N-[(4-fluorophenyl)methyl]-3-propyl-1H-pyrazole-5-carboxamide · in 1 record
- LES · (3S)-N-(pyrimidin-2-yl)azepan-3-amine · in 1 record
- LF4 · N-[(4-fluorophenyl)methyl]-3-(propan-2-yl)-1H-pyrazole-5-carboxamide · in 1 record
- LFJ · 1-[4-(2H-1,3-benzodioxole-5-carbonyl)-2,3,4,5-tetrahydro-1H-1,4-diazepin-1-yl]ethan-1-one · in 1 record
- LFM · N-[(4-fluorophenyl)methyl]-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxamide · in 1 record
- LFP · 5-chloro-N-[(4-fluorophenyl)methyl]-1-methyl-1H-pyrazole-4-carboxamide · in 1 record
- LFY · 1-ethyl-N-[(4-fluorophenyl)methyl]-1H-imidazole-4-carboxamide · in 1 record
- LHM · N-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxamide · in 1 record
- LHS · N-[(4-fluorophenyl)methyl]-5-(methoxymethyl)-1,2,4-oxadiazole-3-carboxamide · in 1 record
Experiment against prediction
- 5QP5 chain A against the predicted model Q8IU60: TM-score 0.90, RMSD 1.41 Å
- 5QOU chain A against the predicted model Q8IU60: TM-score 0.90, RMSD 1.43 Å
- 5QP0 chain A against the predicted model Q8IU60: TM-score 0.90, RMSD 1.43 Å
- 5QP4 chain A against the predicted model Q8IU60: TM-score 0.90, RMSD 1.44 Å
- 5QP4 chain A against the predicted model Q8IU60: TM-score 0.90, RMSD 1.44 Å
- 5QP2 chain A against the predicted model Q8IU60: TM-score 0.90, RMSD 1.45 Å
- 5QOW chain A against the predicted model Q8IU60: TM-score 0.90, RMSD 1.45 Å
- 5QOR chain A against the predicted model Q8IU60: TM-score 0.90, RMSD 1.45 Å
- 5QOR chain A against the predicted model Q8IU60: TM-score 0.90, RMSD 1.45 Å
- 5QOX chain A against the predicted model Q8IU60: TM-score 0.90, RMSD 1.45 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.