UniProt Q8I5R7
Proline--tRNA ligase (Q8I5R7)
Proline--tRNA ligase (UniProt Q8I5R7), EC 6.1.1.15: 25 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 89 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8I5R7
- Protein
- Proline--tRNA ligase
- EC
- 6.1.1.15
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 89 · 9 records with a druggable one
Structures
26 records of Q8I5R7 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4NCX | Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium… | x-ray diffraction | A, B | — | — |
| 4NCX | Crystal structure of prolyl-tRNA synthetase (prors, proline--tRNA ligase) from plasmodium… | x-ray diffraction | A, B | — | — |
| 4OLF | Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase)from Plasmodium falciparum… | x-ray diffraction | A | — | — |
| 4OLF | Crystal structure of prolyl-tRNA synthetase (prors, proline--tRNA LIGASE)FROM plasmodium falciparum… | x-ray diffraction | A | — | — |
| 4Q15 | Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium… | x-ray diffraction | A, B | — | — |
| 4Q15 | Crystal structure of prolyl-tRNA synthetase (prors, proline--tRNA ligase) from plasmodium… | x-ray diffraction | A, B | — | — |
| 4TWA | Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparum | x-ray diffraction | A, B | — | — |
| 4TWA | Crystal structure of prolyl-tRNA synthetase (prs) from plasmodium falciparum | x-ray diffraction | A, B | — | — |
| 4WI1 | Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium… | x-ray diffraction | A, B | — | — |
| 4WI1 | Crystal structure of prolyl-tRNA synthetase (prors, proline--tRNA ligase) from plasmodium… | x-ray diffraction | A, B | — | — |
| 4YDQ | Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparum in complex with… | x-ray diffraction | A, B | — | — |
| 4YDQ | Crystal structure of prolyl-tRNA synthetase (prs) from plasmodium falciparum in complex with… | x-ray diffraction | A, B | — | — |
| 5IFU | Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium… | x-ray diffraction | A, B | GBM, CL | 11 (best 0.75) |
| 5IFU | Crystal structure of prolyl-tRNA synthetase (prors, proline--tRNA ligase) from plasmodium… | x-ray diffraction | A, B | — | — |
| 6T7K | Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium… | x-ray diffraction | A | PRO, MU5 | 6 (best 0.75) |
| 6T7K | Crystal structure of prolyl-tRNA synthetase (prors, proline--tRNA ligase) from plasmodium… | x-ray diffraction | A | MU5 | — |
| 7F96 | Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with L-proline and compound L95 | x-ray diffraction | A | JE6, PRO | 7 (best 0.74) |
| 7F97 | Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with L-proline and compound L97 | x-ray diffraction | A, B, C, D | PRO, 1XK, CL | 20 (best 0.78) |
| 7QB7 | Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline-tRNA ligase) from Plasmodium falciparum… | x-ray diffraction | A | PRO, 9X2 | 6 (best 0.75) |
| 7QB7 | Crystal structure of prolyl-tRNA synthetase (prors, proline-tRNA ligase) from plasmodium falciparum… | x-ray diffraction | A | 9X2 | — |
| 7QC1 | Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline-tRNA ligase) from Plasmodium falciparum… | x-ray diffraction | A, D, I | 9XM | 17 (best 0.77) |
| 7QC1 | Crystal structure of prolyl-tRNA synthetase (prors, proline-tRNA ligase) from plasmodium falciparum… | x-ray diffraction | A, D, I | 9XM | — |
| 7QC2 | Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline-tRNA ligase) from Plasmodium falciparum… | x-ray diffraction | A | PRO, AJT | 8 (best 0.76) |
| 7QC2 | Crystal structure of prolyl-tRNA synthetase (prors, proline-tRNA ligase) from plasmodium falciparum… | x-ray diffraction | A | AJT | — |
| 7V9D | Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with inhibitor L95 and azetidine | x-ray diffraction | A | JE6, 02A | 6 (best 0.76) |
| Q8I5R7 | AlphaFold monomer V2.0 prediction for proline--tRNA ligase (Q8I5R7) | predicted | A | — | 8 (best 0.73) |
Ligands
- PRO · Proline · in 5 records
- 9X2 · ~{N}-(2,3-dihydro-1~{H}-inden-2-yl)-3-[[4-[[[(2~{S})-pyrrolidin-2-yl]carbonylamino]methyl]piperidin-1-yl]carbonylamino]pyrazine-2-carboxamide · in 2 records
- 9XM · [(2~{R},3~{S})-2-[3-(7-bromanyl-6-chloranyl-4-oxidanylidene-quinazolin-3-yl)-2-oxidanylidene-propyl]piperidin-3-yl] ~{N}-[4-[[3-(2,3-dihydro-1~{H}-inden-2-ylcarbamoyl)pyrazin-2-yl]carbamoyl]piperazin-1-yl]sulfonylcarbamate · in 2 records
- AJT · ~{N}-(2,3-dihydro-1~{H}-inden-2-yl)-3-[[4-[[(2~{S})-pyrrolidin-2-yl]carbonylamino]piperidin-1-yl]carbonylamino]pyrazine-2-carboxamide · in 2 records
- CL · Chloride ion · in 2 records
- JE6 · ~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide · in 2 records
- MU5 · ~{N}-(2,3-dihydro-1~{H}-inden-2-yl)-3-(piperidin-1-ylcarbonylamino)pyrazine-2-carboxamide · in 2 records
- 02A · (2S)-azetidine-2-carboxylic acid · in 1 record
- 1XK · 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide · in 1 record
- GBM · 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl) sulfamoyl]phenyl}ethyl)-2-methoxybenzamide · in 1 record
Experiment against prediction
- 7QC1 chain I against the predicted model Q8I5R7: TM-score 1.00, RMSD 0.50 Å
- 7QC1 chain I against the predicted model Q8I5R7: TM-score 1.00, RMSD 0.50 Å
- 4Q15 chain A against the predicted model Q8I5R7: TM-score 1.00, RMSD 0.54 Å
- 4Q15 chain A against the predicted model Q8I5R7: TM-score 1.00, RMSD 0.54 Å
- 4YDQ chain A against the predicted model Q8I5R7: TM-score 0.99, RMSD 0.61 Å
- 4YDQ chain A against the predicted model Q8I5R7: TM-score 0.99, RMSD 0.61 Å
- 7F97 chain D against the predicted model Q8I5R7: TM-score 0.99, RMSD 0.62 Å
- 4YDQ chain B against the predicted model Q8I5R7: TM-score 0.99, RMSD 0.64 Å
- 4YDQ chain B against the predicted model Q8I5R7: TM-score 0.99, RMSD 0.64 Å
- 4OLF chain A against the predicted model Q8I5R7: TM-score 0.99, RMSD 0.70 Å
Elsewhere
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