UniProt Q8HXQ5
Multidrug resistance-associated protein 1 (Q8HXQ5)
Multidrug resistance-associated protein 1 (UniProt Q8HXQ5), EC 7.6.2.2, 7.6.2.3: 9 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 105 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8HXQ5
- Protein
- Multidrug resistance-associated protein 1
- EC
- 7.6.2.2, 7.6.2.3
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 105 · 6 records with a druggable one
Structures
10 records of Q8HXQ5 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5UJ9 | Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) | electron microscopy | A | — | 14 (best 0.84) |
| 5UJ9 | Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) | electron microscopy | A | — | — |
| 5UJA | Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) bound to leukotriene C4 | electron microscopy | A | LTX | 18 (best 0.87) |
| 5UJA | Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) bound to leukotriene C4 | electron microscopy | A | LTX | — |
| 6BHU | Cryo-EM structure of ATP-bound, outward-facing bovine multidrug resistance protein 1 (MRP1) | electron microscopy | A | ATP, MG, CLR | 20 (best 0.89) |
| 6BHU | Cryo-EM structure of ATP-bound, outward-facing bovine multidrug resistance protein 1 (MRP1) | electron microscopy | A | ATP, MG, CLR | — |
| 6UY0 | Cryo-EM structure of wild-type bovine multidrug resistance protein 1 (MRP1) under active turnover… | electron microscopy | A | ATP, ADP, MG, CLR | 20 (best 0.89) |
| 6UY0 | Cryo-EM structure of wild-type bovine multidrug resistance protein 1 (MRP1) under active turnover… | electron microscopy | A | ATP, ADP, MG, CLR | — |
| 8F4B | Bovine multidrug resistance protein 1 (MRP1) bound to cyclic peptide inhibitor 1 (CPI1) | electron microscopy | A | — | 14 (best 0.88) |
| Q8HXQ5 | AlphaFold monomer V2.0 prediction for multidrug resistance-associated protein 1 (Q8HXQ5) | predicted | A | — | 19 (best 0.86) |
Ligands
- ATP · Adenosine-5'-triphosphate · in 4 records
- CLR · Cholesterol · in 4 records
- MG · Magnesium ion · in 4 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- LTX · (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11, 14-tetraenoic acid · in 2 records
Experiment against prediction
- 5UJA chain A against the predicted model Q8HXQ5: TM-score 0.95, RMSD 2.90 Å
- 5UJA chain A against the predicted model Q8HXQ5: TM-score 0.95, RMSD 2.90 Å
- 6UY0 chain A against the predicted model Q8HXQ5: TM-score 0.87, RMSD 4.52 Å
- 6UY0 chain A against the predicted model Q8HXQ5: TM-score 0.87, RMSD 4.52 Å
- 6BHU chain A against the predicted model Q8HXQ5: TM-score 0.86, RMSD 4.91 Å
- 6BHU chain A against the predicted model Q8HXQ5: TM-score 0.86, RMSD 4.91 Å
- 5UJ9 chain A against the predicted model Q8HXQ5: TM-score 0.81, RMSD 5.98 Å
- 5UJ9 chain A against the predicted model Q8HXQ5: TM-score 0.81, RMSD 5.98 Å
- 8F4B chain A against the predicted model Q8HXQ5: TM-score 0.80, RMSD 6.08 Å
Elsewhere
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