UniProt Q89ZI2
O-GlcNAcase BT_4395 (Q89ZI2)
O-GlcNAcase BT_4395 (UniProt Q89ZI2), EC 3.2.1.169, 3.2.1.52: 60 experimental structures on GenesisL1, 12 ligands bound, 63 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q89ZI2
- Protein
- O-GlcNAcase BT_4395
- EC
- 3.2.1.169, 3.2.1.52
- Experimental structures
- 60
- Predicted models
- 0
- Ligands
- 12
- Pockets
- 63 · 4 records with a druggable one
Structures
60 records of Q89ZI2 in the MolNFT archive: 60 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2CHN | Bacteroides thetaiotaomicron hexosaminidase with O-GlcNAcase activity- NAG-thiazoline complex | x-ray diffraction | A, B | — | — |
| 2CHN | Bacteroides thetaiotaomicron hexosaminidase with O-glcnacase activity- nag-thiazoline complex | x-ray diffraction | A, B | — | — |
| 2CHO | Bacteroides thetaiotaomicron hexosaminidase with O-GlcNAcase activity | x-ray diffraction | A, B | — | — |
| 2CHO | Bacteroides thetaiotaomicron hexosaminidase with O- glcnacase activity | x-ray diffraction | A, B | — | — |
| 2J47 | Bacteroides thetaiotaomicron GH84 O-GlcNAcase in complex with a imidazole-pugnac hybrid inhibitor | x-ray diffraction | A | — | — |
| 2J47 | Bacteroides thetaiotaomicron GH84 O-glcnacase in complex with a imidazole-pugnac hybrid inhibitor | x-ray diffraction | A | — | — |
| 2J4G | Bacteroides thetaiotaomicron GH84 O-GlcNAcase in complex with n-butyl- thiazoline inhibitor | x-ray diffraction | A, B | — | — |
| 2J4G | Bacteroides thetaiotaomicron GH84 O-glcnacase in complex with N-butyl-thiazoline inhibitor | x-ray diffraction | A, B | — | — |
| 2JIW | Bacteroides thetaiotaomicron GH84 O-GlcNAcase in complex with 2… | x-ray diffraction | A, B | — | — |
| 2JIW | Bacteroides thetaiotaomicron GH84 O-glcnacase in complex with 2-acetylamino-2-deoxy-1-epivalienamine | x-ray diffraction | A, B | — | — |
| 2VVN | BtGH84 in complex with NH-Butylthiazoline | x-ray diffraction | A, B | — | — |
| 2VVN | BTGH84 in complex with nh-butylthiazoline | x-ray diffraction | A, B | — | — |
| 2VVS | BtGH84 structure in complex with PUGNAc | x-ray diffraction | A | — | — |
| 2VVS | BTGH84 structure in complex with pugnac | x-ray diffraction | A | — | — |
| 2W4X | BtGH84 in complex with STZ | x-ray diffraction | A | — | — |
| 2W4X | BTGH84 in complex with stz | x-ray diffraction | A | — | — |
| 2W66 | BtGH84 in complex with HQ602 | x-ray diffraction | A, B | — | — |
| 2W66 | BTGH84 in complex with HQ602 | x-ray diffraction | A, B | — | — |
| 2W67 | BtGH84 in complex with FMA34 | x-ray diffraction | A, B | — | — |
| 2W67 | BTGH84 in complex with FMA34 | x-ray diffraction | A, B | — | — |
| 2WCA | BtGH84 in complex with n-butyl pugnac | x-ray diffraction | A | — | — |
| 2WCA | BTGH84 in complex with N-butyl pugnac | x-ray diffraction | A | — | — |
| 2WZH | BtGH84 D242N in complex with MeUMB-derived oxazoline | x-ray diffraction | A | — | — |
| 2WZH | BTGH84 D242N in complex with meumb-derived oxazoline | x-ray diffraction | A | — | — |
| 2WZI | BtGH84 D243N in complex with 5F-oxazoline | x-ray diffraction | A, B | — | — |
| 2WZI | BTGH84 D243N in complex with 5F-oxazoline | x-ray diffraction | A, B | — | — |
| 2X0H | BtGH84 Michaelis complex | x-ray diffraction | A, B | — | — |
| 2X0H | BTGH84 michaelis complex | x-ray diffraction | A, B | — | — |
| 2XJ7 | BtGH84 in complex with 6-acetamido-6-deoxy-castanospermine | x-ray diffraction | A, B | — | — |
| 2XJ7 | BTGH84 in complex with 6-acetamido-6-deoxy-castanospermine | x-ray diffraction | A, B | — | — |
| 2XM1 | BtGH84 in complex with N-acetyl gluconolactam | x-ray diffraction | A, B | — | — |
| 2XM1 | BTGH84 in complex with N-acetyl gluconolactam | x-ray diffraction | A, B | — | — |
| 2XM2 | BtGH84 in complex with LOGNAc | x-ray diffraction | A, B | — | — |
| 2XM2 | BTGH84 in complex with lognac | x-ray diffraction | A, B | — | — |
| 4AIS | A complex structure of BtGH84 | x-ray diffraction | A, B | — | — |
| 4AIS | A complex structure of BTGH84 | x-ray diffraction | A, B | — | — |
| 4AIU | A complex structure of BtGH84 | x-ray diffraction | A | — | — |
| 4AIU | A complex structure of BTGH84 | x-ray diffraction | A | — | — |
| 4UR9 | Structure of ligand bound glycosylhydrolase | x-ray diffraction | A, B | — | — |
| 4UR9 | Structure of ligand bound glycosylhydrolase | x-ray diffraction | A, B | — | — |
| 5ABE | Structure of GH84 with ligand | x-ray diffraction | A, B | — | — |
| 5ABF | Structure of GH84 with ligand | x-ray diffraction | A, B | XRJ, CA | 20 (best 0.67) |
| 5ABF | Structure of GH84 with ligand | x-ray diffraction | A, B | — | — |
| 5ABG | Structure of GH84 with ligand | x-ray diffraction | A, B | — | — |
| 5ABH | Structure of GH84 with ligand | x-ray diffraction | A, B | CL, YWN, CA | 20 (best 0.69) |
| 5ABH | Structure of GH84 with ligand | x-ray diffraction | A, B | — | — |
| 5FKY | Structure of a hydrolase bound with an inhibitor | x-ray diffraction | A, B | 2J4 | 16 (best 0.62) |
| 5FKY | Structure of a hydrolase bound with an inhibitor | x-ray diffraction | A, B | — | — |
| 5FL0 | Structure of a hydrolase with an inhibitor | x-ray diffraction | A, B | 71I, CA | — |
| 5FL0 | Structure of a hydrolase with an inhibitor | x-ray diffraction | A, B | — | — |
| 5FL1 | Structure of a hydrolase with an inhibitor | x-ray diffraction | A, B | DV1, CA | — |
| 5FL1 | Structure of a hydrolase with an inhibitor | x-ray diffraction | A, B | — | — |
| 5MI4 | BtGH84 mutant with covalent modification by MA3 | x-ray diffraction | A | 7NQ, CA | 7 (best 0.63) |
| 5MI4 | BTGH84 mutant with covalent modification by MA3 | x-ray diffraction | A | 7NQ, CA | — |
| 5MI5 | BTGH84 mutant with covalent modification by MA3 in complex with pugnac | x-ray diffraction | A | OAN, 7NQ, CA | — |
| 5MI6 | BTGH84 mutant with covalent modification by MA3 in complex with thiamet G | x-ray diffraction | A | NHT, 7NQ, CA | — |
| 5MI7 | BtGH84 mutant with covalent modification by MA4 in complex with PUGNAc | x-ray diffraction | A | OAN, 7NT, CA | — |
| 5MI7 | BTGH84 mutant with covalent modification by MA4 in complex with pugnac | x-ray diffraction | A | OAN, 7NT, CA | — |
| 7K41 | Bacterial O-glcnacase (oga) with compound | x-ray diffraction | A | VUA | — |
| Q89ZI2 | AlphaFold monomer V2.0 prediction for O-glcnacase BT_4395 (Q89ZI2) | — | — | — |
Ligands
- CA · Calcium ion · in 10 records
- 7NQ · ~{N}-(4-ethoxyquinazolin-2-yl)propanamide · in 4 records
- OAN · O-(2-acetamido-2-deoxy D-glucopyranosylidene) amino-N-phenylcarbamate · in 3 records
- 7NT · ~{N}-(4-morpholin-4-ylthieno[2,3-d]pyrimidin-2-yl) propanamide · in 2 records
- 2J4 · (3aR,5R,6S,7R,7aR)-2-amino-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol · in 1 record
- 71I · (3~{a}~{R},5~{R},6~{S},7~{R},7~{a}~{R})-2-(butylamino)-5-(hydroxymethyl)-5,6,7,7~{a}-tetrahydro-3~{a}~{H}-pyrano[3,2-d] [1,3]thiazole-6,7-diol · in 1 record
- CL · Chloride ion · in 1 record
- DV1 · (3~{a}~{R},5~{R},6~{S},7~{R},7~{a}~{R})-5-(hydroxymethyl)-2-(prop-2-enylamino)-5,6,7,7~{a}-tetrahydro-3~{a}~{H}-pyrano[3,2-d][1,3]thiazole-6,7-diol · in 1 record
- NHT · (3ar,5r,6s,7r,7ar)-2-(ethylamino)-5-(hydroxymethyl)-5, 6,7,7A-tetrahydro-3AH-pyrano[3,2-d][1,3]thiazole-6,7-diol · in 1 record
- VUA · 4-(4-methylpiperidin-1-yl)-N-(2-phenylethyl)pyrimidin-2-amine · in 1 record
- XRJ · 2-[(2S,3R,4R,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)-1-pentyl-pyrrolidin-2-yl]-N-methyl-ethanamide · in 1 record
- YWN · 2-[(2R,3S,4R,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)-1-pentyl-pyrrolidin-2-yl]-N-methyl-ethanamide · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.