UniProt Q86Y07
Serine/threonine-protein kinase VRK2 (Q86Y07)
Serine/threonine-protein kinase VRK2 (UniProt Q86Y07), EC 2.7.11.1: 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q86Y07
- Protein
- Serine/threonine-protein kinase VRK2
- EC
- 2.7.11.1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 24 · 5 records with a druggable one
Structures
9 records of Q86Y07 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2V62 | Structure of vaccinia-related kinase 2 | x-ray diffraction | A, B | — | — |
| 2V62 | Structure of vaccinia-related kinase 2 | x-ray diffraction | A, B | — | — |
| 5UU1 | Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to BI-D1870 | x-ray diffraction | A | 7DZ | 3 (best 0.59) |
| 5UU1 | Crystal structure of human vaccinia-related kinase 2 (vrk-2) bound to bi-D1870 | x-ray diffraction | A | 7DZ | — |
| 6NCG | Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to pyridin-benzenesulfonamide… | x-ray diffraction | A, B | KJD, SO4 | 7 (best 0.66) |
| 6NCG | Crystal structure of human vaccinia-related kinase 2 (vrk-2) bound to pyridin-benzenesulfonamide… | x-ray diffraction | A, B | KJD, SO4 | — |
| 8Q1Z | Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to JA-296 | x-ray diffraction | A | IKD | 2 (best 0.55) |
| 9FET | Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to JA-47 | x-ray diffraction | A | REB | 7 (best 0.66) |
| Q86Y07 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase VRK2 (Q86Y07) | predicted | A | — | 5 (best 0.77) |
Ligands
- 7DZ · (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one · in 2 records
- KJD · 4-[6-amino-5-(3,5-difluoro-4-hydroxyphenyl)pyridin-3-yl]benzene-1-sulfonamide · in 2 records
- SO4 · Sulfate ion · in 2 records
- IKD · 2-[4-[[4-[(3-~{tert}-butyl-1~{H}-pyrazol-5-yl)amino]pyrimidin-2-yl]amino]phenyl]ethanenitrile · in 1 record
- REB · [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile · in 1 record
Experiment against prediction
- 9FET chain A against the predicted model Q86Y07: TM-score 0.99, RMSD 0.61 Å
- 8Q1Z chain A against the predicted model Q86Y07: TM-score 0.99, RMSD 0.64 Å
- 2V62 chain A against the predicted model Q86Y07: TM-score 0.99, RMSD 0.67 Å
- 2V62 chain A against the predicted model Q86Y07: TM-score 0.99, RMSD 0.67 Å
- 2V62 chain B against the predicted model Q86Y07: TM-score 0.99, RMSD 0.75 Å
- 2V62 chain B against the predicted model Q86Y07: TM-score 0.99, RMSD 0.75 Å
- 5UU1 chain A against the predicted model Q86Y07: TM-score 0.98, RMSD 1.05 Å
- 5UU1 chain A against the predicted model Q86Y07: TM-score 0.98, RMSD 1.05 Å
- 6NCG chain A against the predicted model Q86Y07: TM-score 0.98, RMSD 0.99 Å
- 6NCG chain A against the predicted model Q86Y07: TM-score 0.98, RMSD 0.99 Å
Elsewhere
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