UniProt Q86Y01
E3 ubiquitin-protein ligase DTX1 (Q86Y01)
E3 ubiquitin-protein ligase DTX1 (UniProt Q86Y01), EC 2.3.2.27: 6 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q86Y01
- Protein
- E3 ubiquitin-protein ligase DTX1
- EC
- 2.3.2.27
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 17 · 4 records with a druggable one
Structures
7 records of Q86Y01 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6Y5N | RING-DTC domain of Deltex1 | x-ray diffraction | A, B | ZN, CL | 5 (best 0.63) |
| 6Y5N | Ring-dtc domain of DELTEX1 | x-ray diffraction | A, B | ZN, CL | — |
| 6Y5P | RING-DTC domain of Deltex1 bound to NAD | x-ray diffraction | A, B | NAD, ZN | 4 (best 0.65) |
| 6Y5P | Ring-dtc domain of DELTEX1 bound to NAD | x-ray diffraction | A, B | NAD, ZN | — |
| 8R5N | DTX1 WWE domain in complex with ATP | x-ray diffraction | A, B | ATP | 4 (best 0.53) |
| 8R6A | DTX1 WWE domain in complex with ADP bound to WWE1 | x-ray diffraction | A, B | ADP | 4 (best 0.53) |
| Q86Y01 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase DTX1 (Q86Y01) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8R6A chain B against the predicted model Q86Y01: TM-score 0.98, RMSD 0.80 Å
- 8R5N chain B against the predicted model Q86Y01: TM-score 0.97, RMSD 0.96 Å
- 8R6A chain A against the predicted model Q86Y01: TM-score 0.97, RMSD 0.92 Å
- 8R5N chain A against the predicted model Q86Y01: TM-score 0.97, RMSD 0.97 Å
- 6Y5P chain A against the predicted model Q86Y01: TM-score 0.85, RMSD 2.56 Å
- 6Y5P chain A against the predicted model Q86Y01: TM-score 0.85, RMSD 2.56 Å
- 6Y5N chain A against the predicted model Q86Y01: TM-score 0.85, RMSD 2.61 Å
- 6Y5N chain A against the predicted model Q86Y01: TM-score 0.85, RMSD 2.61 Å
- 6Y5N chain B against the predicted model Q86Y01: TM-score 0.85, RMSD 2.63 Å
- 6Y5N chain B against the predicted model Q86Y01: TM-score 0.85, RMSD 2.63 Å
Elsewhere
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