UniProt Q86TI2
Dipeptidyl peptidase 9 (Q86TI2)
Dipeptidyl peptidase 9 (UniProt Q86TI2), EC 3.4.14.5: 15 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 88 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q86TI2
- Protein
- Dipeptidyl peptidase 9
- EC
- 3.4.14.5
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 88 · 5 records with a druggable one
Structures
16 records of Q86TI2 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6EOQ | DPP9 - APO | x-ray diffraction | A, B, C, D | — | — |
| 6EOR | DPP9 - 1G244 | x-ray diffraction | A, B, C, D | 9XH | — |
| 6QZV | DPP9 bound to a dipeptide (MP) from the N-terminus of BRCA2 | x-ray diffraction | A, B, C, D | — | — |
| 6QZV | DPP9 bound to a dipeptide (mp) from the N-terminus of BRCA2 | x-ray diffraction | A, B, C, D | — | — |
| 6X6A | Cryo-EM structure of NLRP1-DPP9 complex | electron microscopy | A, D | — | 15 (best 0.85) |
| 6X6A | Cryo-EM structure of NLRP1-DPP9 complex | electron microscopy | A, D | — | — |
| 6X6C | Cryo-EM structure of NLRP1-DPP9-VbP complex | electron microscopy | A, D | GK2 | 18 (best 0.83) |
| 6X6C | Cryo-EM structure of NLRP1-DPP9-vbp complex | electron microscopy | A, D | GK2 | — |
| 7A3F | Crystal structure of apo DPP9 | x-ray diffraction | B, A, C, D | PO4 | 20 (best 0.84) |
| 7A3F | Crystal structure of apo DPP9 | x-ray diffraction | B, A, C, D | PO4 | — |
| 7JKQ | Human DPP9-CARD8 complex | electron microscopy | A, D | — | — |
| 7JN7 | Human DPP9-CARD8 complex | electron microscopy | A, D | GK2 | 15 (best 0.83) |
| 7JN7 | Human DPP9-CARD8 complex | electron microscopy | A, D | GK2 | — |
| 7SVL | DPP9 IN COMPLEX WITH LIGAND ICeD-2 | x-ray diffraction | A, B, C, D | D06 | 20 (best 0.84) |
| 7ZXS | Crystal structure of DPP9 in complex with a 4-oxo-b-lactam based inhibitor, A295 | x-ray diffraction | A, B, C, D | KBO | — |
| Q86TI2 | AlphaFold monomer V2.0 prediction for dipeptidyl peptidase 9 (Q86TI2) | predicted | A | — | — |
Ligands
- GK2 · [(2~{R})-1-[(2~{R})-2-azanyl-3-methyl-butanoyl]pyrrolidin-2-yl]boronic acid · in 4 records
- PO4 · Phosphate ion · in 2 records
- 9XH · (2~{S})-2-azanyl-4-[4-[bis(4-fluorophenyl) methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl) butane-1,4-dione · in 1 record
- D06 · (2S)-2-amino-1-(1,3-dihydro-2H-isoindol-2-yl)-2-[(1r,4S)-4-(pyrrolidin-1-yl)cyclohexyl]ethan-1-one · in 1 record
- KBO · 2-ethyl-2-methanoyl-~{N}-[3-[[4-(quinolin-8-ylmethyl)piperazin-1-yl]methyl]phenyl]butanamide · in 1 record
Experiment against prediction
- 6EOR chain C against the predicted model Q86TI2: TM-score 1.00, RMSD 0.67 Å
- 6QZV chain C against the predicted model Q86TI2: TM-score 1.00, RMSD 0.67 Å
- 6QZV chain C against the predicted model Q86TI2: TM-score 1.00, RMSD 0.67 Å
- 6EOR chain B against the predicted model Q86TI2: TM-score 1.00, RMSD 0.69 Å
- 6EOR chain D against the predicted model Q86TI2: TM-score 1.00, RMSD 0.69 Å
- 6QZV chain B against the predicted model Q86TI2: TM-score 0.99, RMSD 0.70 Å
- 6QZV chain B against the predicted model Q86TI2: TM-score 0.99, RMSD 0.70 Å
- 6QZV chain D against the predicted model Q86TI2: TM-score 0.99, RMSD 0.72 Å
- 6QZV chain D against the predicted model Q86TI2: TM-score 0.99, RMSD 0.72 Å
- 7SVL chain B against the predicted model Q86TI2: TM-score 0.99, RMSD 0.76 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.