UniProt Q86SQ9
Dehydrodolichyl diphosphate synthase complex subunit DHDDS (Q86SQ9)
Dehydrodolichyl diphosphate synthase complex subunit DHDDS (UniProt Q86SQ9), EC 2.5.1.87: 12 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 35 pockets. Binding sites, druggability and experiment…
- UniProt
- Q86SQ9
- Protein
- Dehydrodolichyl diphosphate synthase complex subunit DHDDS
- EC
- 2.5.1.87
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 35 · 6 records with a druggable one
Structures
13 records of Q86SQ9 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6W2L | Crystal structure of human dehydrodolichyl diphosphate synthase (NgBR/DHDDS) in complex with Mg and… | x-ray diffraction | A | MG, IPE | 6 (best 0.83) |
| 6W2L | Crystal structure of human dehydrodolichyl diphosphate synthase (NGBR/DHDDS) in complex with mg and… | x-ray diffraction | A | MG, IPE | — |
| 6Z1N | Structure of the human heterotetrameric cis-prenyltransferase complex | x-ray diffraction | A | FPP, PO4, MG | 8 (best 0.82) |
| 6Z1N | Structure of the human heterotetrameric cis-prenyltransferase complex | x-ray diffraction | A | FPP, PO4, MG | — |
| 7PAX | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium… | x-ray diffraction | A | IPE, FPS, MG | 6 (best 0.84) |
| 7PAX | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium… | x-ray diffraction | A | IPE, FPS, MG | — |
| 7PAY | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium and… | x-ray diffraction | A | SO4, MG, GGS | 6 (best 0.83) |
| 7PAY | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium and… | x-ray diffraction | A | SO4, MG, GGS | — |
| 7PB0 | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium… | x-ray diffraction | A | ISY, GGS, MG | 5 (best 0.83) |
| 7PB0 | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium… | x-ray diffraction | A | ISY, GGS, MG | — |
| 7PB1 | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium… | x-ray diffraction | A | MG, GRG, ISY | 4 (best 0.80) |
| 7PB1 | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium… | x-ray diffraction | A | MG, GRG, ISY | — |
| Q86SQ9 | AlphaFold monomer V2.0 prediction for dehydrodolichyl diphosphate synthase complex subunit dhdds… | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 12 records
- GGS · Phosphonooxy-[(10E)-3,7,11,15-tetramethylhexadeca-2,6, 10,14-tetraenyl]sulfanyl-phosphinic acid · in 4 records
- IPE · 3-methylbut-3-enyl trihydrogen diphosphate · in 4 records
- ISY · 3-methylbut-3-enylsulfanyl(phosphonooxy)phosphinic acid · in 4 records
- FPP · Farnesyl diphosphate · in 2 records
- FPS · S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl] trihydrogen thiodiphosphate · in 2 records
- GRG · Geranylgeranyl diphosphate · in 2 records
- PO4 · Phosphate ion · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 6W2L chain A against the predicted model Q86SQ9: TM-score 0.99, RMSD 0.65 Å
- 6W2L chain A against the predicted model Q86SQ9: TM-score 0.99, RMSD 0.65 Å
- 7PB1 chain A against the predicted model Q86SQ9: TM-score 0.99, RMSD 0.88 Å
- 7PB1 chain A against the predicted model Q86SQ9: TM-score 0.99, RMSD 0.88 Å
- 7PAX chain A against the predicted model Q86SQ9: TM-score 0.99, RMSD 0.89 Å
- 7PAX chain A against the predicted model Q86SQ9: TM-score 0.99, RMSD 0.89 Å
- 7PB0 chain A against the predicted model Q86SQ9: TM-score 0.98, RMSD 0.92 Å
- 7PB0 chain A against the predicted model Q86SQ9: TM-score 0.98, RMSD 0.92 Å
- 7PAY chain A against the predicted model Q86SQ9: TM-score 0.98, RMSD 0.89 Å
- 7PAY chain A against the predicted model Q86SQ9: TM-score 0.98, RMSD 0.89 Å
Elsewhere
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