UniProt Q7YRZ8
E3 ubiquitin-protein ligase Mdm2 (Q7YRZ8)
E3 ubiquitin-protein ligase Mdm2 (UniProt Q7YRZ8), EC 2.3.2.27: 9 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q7YRZ8
- Protein
- E3 ubiquitin-protein ligase Mdm2
- EC
- 2.3.2.27
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 18 · 2 records with a druggable one
Structures
10 records of Q7YRZ8 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6SQP | Crystal structure of Cat MDM2-S429E RING domain homodimer | x-ray diffraction | A, B, C, D | ZN, CL, NO3 | 2 (best 0.38) |
| 6SQP | Crystal structure of cat MDM2-S429E ring domain homodimer | x-ray diffraction | A, B, C, D | ZN, CL, NO3 | — |
| 6SQR | Crystal structure of Cat MDM2-S429E RING domain bound to UbcH5B-Ub | x-ray diffraction | A, D, G, J | ZN, NO3 | 12 (best 0.72) |
| 6SQR | Crystal structure of cat MDM2-S429E ring domain bound to UBCH5B-ub | x-ray diffraction | A, D, G, J | ZN, NO3 | — |
| 6SQS | Crystal structure of cat phospho-Ser429 MDM2 RING domain bound to UbcH5B-Ub | x-ray diffraction | A, D | ZN | 4 (best 0.64) |
| 6SQS | Crystal structure of cat phospho-SER429 MDM2 ring domain bound to UBCH5B-ub | x-ray diffraction | A, D | ZN | — |
| 7T59 | Structure of mouse double minute 2 homolog (MDM2) ring domain | x-ray diffraction | A, B, C, D | ZN, CL | — |
| 7TFG | Structure of mouse double minute 2 homolog (MDM2) ring domain in complex with MA242 | x-ray diffraction | A, B, C, D | ZN, I2S | — |
| 7THL | Structure of mouse double minute 2 homolog (MDM2) ring domain in complex with inulanolide a | x-ray diffraction | A, B, C, D | ZN, CL, I61 | — |
| Q7YRZ8 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase MDM2 (Q7YRZ8) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7T59 chain C against the predicted model Q7YRZ8: TM-score 0.93, RMSD 0.89 Å
- 7T59 chain A against the predicted model Q7YRZ8: TM-score 0.92, RMSD 0.89 Å
- 7THL chain A against the predicted model Q7YRZ8: TM-score 0.91, RMSD 1.12 Å
- 7TFG chain A against the predicted model Q7YRZ8: TM-score 0.90, RMSD 1.57 Å
- 6SQR chain G against the predicted model Q7YRZ8: TM-score 0.90, RMSD 1.50 Å
- 6SQR chain G against the predicted model Q7YRZ8: TM-score 0.90, RMSD 1.50 Å
- 6SQP chain A against the predicted model Q7YRZ8: TM-score 0.90, RMSD 1.16 Å
- 6SQP chain A against the predicted model Q7YRZ8: TM-score 0.90, RMSD 1.16 Å
- 6SQR chain J against the predicted model Q7YRZ8: TM-score 0.89, RMSD 1.86 Å
- 6SQS chain A against the predicted model Q7YRZ8: TM-score 0.89, RMSD 1.86 Å
Elsewhere
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