UniProt Q7L2J0
7SK snRNA methylphosphate capping enzyme (Q7L2J0)
7SK snRNA methylphosphate capping enzyme (UniProt Q7L2J0), EC 2.1.1.-: 9 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q7L2J0
- Protein
- 7SK snRNA methylphosphate capping enzyme
- EC
- 2.1.1.-
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 21 · 4 records with a druggable one
Structures
10 records of Q7L2J0 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5UNA | Fragment of 7SK snRNA methylphosphate capping enzyme | x-ray diffraction | A, B, C, D, E, F | SAH | 8 (best 0.78) |
| 5UNA | Fragment of 7SK snrna methylphosphate capping enzyme | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6DCB | Structure of methylphosphate capping enzyme methyltransferase domain in complex with 5' end of 7SK… | x-ray diffraction | A | SAH, SO4 | 2 (best 0.79) |
| 6DCB | Structure of methylphosphate capping enzyme methyltransferase domain in complex with 5' end of 7SK… | x-ray diffraction | A | SO4 | — |
| 6DCC | Structure of methylphosphate capping enzyme methyltransferase domain in complex with 5' end of 7SK… | x-ray diffraction | A | SAH, SO4 | 2 (best 0.77) |
| 6DCC | Structure of methylphosphate capping enzyme methyltransferase domain in complex with 5' end of 7SK… | x-ray diffraction | A | SO4 | — |
| 7SLP | Cryo-EM structure of 7SK core RNP with linear RNA | electron microscopy | A | SAH | 9 (best 0.77) |
| 7SLP | Cryo-EM structure of 7SK core rnp with linear RNA | electron microscopy | A | — | — |
| 7SLQ | Cryo-EM structure of 7SK core rnp with circular RNA | electron microscopy | A | — | — |
| Q7L2J0 | AlphaFold monomer V2.0 prediction for 7SK snrna methylphosphate capping enzyme (Q7L2J0) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6DCB chain A against the predicted model Q7L2J0: TM-score 0.99, RMSD 0.47 Å
- 6DCC chain A against the predicted model Q7L2J0: TM-score 0.99, RMSD 0.44 Å
- 6DCB chain A against the predicted model Q7L2J0: TM-score 0.99, RMSD 0.47 Å
- 6DCC chain A against the predicted model Q7L2J0: TM-score 0.99, RMSD 0.44 Å
- 5UNA chain A against the predicted model Q7L2J0: TM-score 0.98, RMSD 1.16 Å
- 5UNA chain B against the predicted model Q7L2J0: TM-score 0.98, RMSD 1.18 Å
- 5UNA chain D against the predicted model Q7L2J0: TM-score 0.97, RMSD 1.22 Å
- 5UNA chain F against the predicted model Q7L2J0: TM-score 0.97, RMSD 1.22 Å
- 5UNA chain E against the predicted model Q7L2J0: TM-score 0.97, RMSD 1.20 Å
- 5UNA chain A against the predicted model Q7L2J0: TM-score 0.97, RMSD 1.16 Å
Elsewhere
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