UniProt Q70LM7
Linear gramicidin synthase subunit A (Q70LM7)
Linear gramicidin synthase subunit A (UniProt Q70LM7): 21 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q70LM7
- Protein
- Linear gramicidin synthase subunit A
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 24 · 2 records with a druggable one
Structures
22 records of Q70LM7 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ES5 | Crystal structure of the initiation module of LgrA in the open" and "closed " adenylation states" | x-ray diffraction | A, B | SO4 | — |
| 5ES5 | Crystal structure of the initiation module of lgra in the "open" and "closed " adenylation states | x-ray diffraction | A, B | — | — |
| 5ES6 | Crystal structure of the first two domains of the initiation module of LgrA | x-ray diffraction | A | — | 5 (best 0.71) |
| 5ES6 | Crystal structure of the first two domains of the initiation module of lgra | x-ray diffraction | A | — | — |
| 5ES7 | Crystal structure of the F-a domains of the lgra initiation module soaked with fon, ampcpp, and… | x-ray diffraction | A | — | — |
| 5ES8 | Crystal structure of the initiation module of LgrA in the thiolation state | x-ray diffraction | A, B | 5S4 | — |
| 5ES8 | Crystal structure of the initiation module of lgra in the thiolation state | x-ray diffraction | A, B | — | — |
| 5ES9 | Crystal structure of the LgrA initiation module in the formylation state | x-ray diffraction | A, B | PNS | — |
| 5ES9 | Crystal structure of the lgra initiation module in the formylation state | x-ray diffraction | A, B | — | — |
| 5JNF | Crystal structure of the LgrA initiation module excluding the Asub domain: F-A-delta-sub | x-ray diffraction | C, A, B, D | — | 19 (best 0.78) |
| 5JNF | Crystal structure of the lgra initiation module excluding the asub domain: F-a-delta-sub | x-ray diffraction | C, A, B, D | — | — |
| 6MFW | Crystal structure of a 4-domain construct of lgra in the substrate donation state | x-ray diffraction | A | JQG, APC, PO4 | — |
| 6MFX | Crystal structure of a 4-domain construct of a mutant of LgrA in the substrate donation state | x-ray diffraction | A | 9EF, APC | — |
| 6MFX | Crystal structure of a 4-domain construct of a mutant of lgra in the substrate donation state | x-ray diffraction | A | 9EF, APC | — |
| 6MFY | Crystal structure of a 5-domain construct of LgrA in the substrate donation state | x-ray diffraction | A | PNS, PO4 | — |
| 6MFY | Crystal structure of a 5-domain construct of lgra in the substrate donation state | x-ray diffraction | A | PNS, PO4 | — |
| 6MFZ | Crystal structure of dimodular LgrA in a condensation state | x-ray diffraction | A, B | PNS | — |
| 6MFZ | Crystal structure of dimodular lgra in a condensation state | x-ray diffraction | A, B | PNS | — |
| 6MG0 | Crystal structure of a 5-domain construct of LgrA in the thiolation state | x-ray diffraction | A, B | — | — |
| 6MG0 | Crystal structure of a 5-domain construct of lgra in the thiolation state | x-ray diffraction | A, B | — | — |
| 6ULZ | Adenylation domain of the initiation module of lgra mutant P483M | x-ray diffraction | A | APC, KIV | — |
| Q70LM7 | AlphaFold monomer V2.0 prediction for linear gramicidin synthase subunit a (Q70LM7) | predicted | A | — | — |
Ligands
- PNS · 4'-phosphopantetheine · in 5 records
- APC · Diphosphomethylphosphonic acid adenosyl ester · in 4 records
- PO4 · Phosphate ion · in 3 records
- 9EF · N-[2-(acetylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide · in 2 records
- 5S4 · [(3~{R})-4-[[3-[2-[[(2~{S})-2-azanyl-3-methyl-butanoyl]amino]ethylamino]-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] dihydrogen phosphate · in 1 record
- JQG · (2~{R})-~{N}-[3-[2-[[(2~{S})-2-formamido-3-methyl-butanoyl]amino]ethylamino]-3-oxidanylidene-propyl]-3, 3-dimethyl-2-oxidanyl-4-[oxidanyl-bis(oxidanylidene)-$L^{6}-phosphanyl]oxy-butanamide · in 1 record
- KIV · 3-methyl-2-oxobutanoic acid · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 6MFZ chain A against the predicted model Q70LM7: TM-score 0.99, RMSD 1.41 Å
- 6MFZ chain A against the predicted model Q70LM7: TM-score 0.99, RMSD 1.41 Å
- 6MFW chain A against the predicted model Q70LM7: TM-score 0.99, RMSD 1.24 Å
- 5JNF chain A against the predicted model Q70LM7: TM-score 0.98, RMSD 1.26 Å
- 5JNF chain A against the predicted model Q70LM7: TM-score 0.98, RMSD 1.26 Å
- 5JNF chain C against the predicted model Q70LM7: TM-score 0.98, RMSD 1.26 Å
- 5JNF chain C against the predicted model Q70LM7: TM-score 0.98, RMSD 1.26 Å
- 6MFX chain A against the predicted model Q70LM7: TM-score 0.98, RMSD 1.68 Å
- 6MFX chain A against the predicted model Q70LM7: TM-score 0.98, RMSD 1.68 Å
- 5ES6 chain A against the predicted model Q70LM7: TM-score 0.98, RMSD 1.28 Å
Elsewhere
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