UniProt Q6ZQJ5
DNA replication ATP-dependent helicase/nuclease DNA2 (Q6ZQJ5)
DNA replication ATP-dependent helicase/nuclease DNA2 (UniProt Q6ZQJ5), EC 3.1.-.-, 3.6.4.12: 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 20 pockets. Binding sites, druggability and experiment…
- UniProt
- Q6ZQJ5
- Protein
- DNA replication ATP-dependent helicase/nuclease DNA2
- EC
- 3.1.-.-, 3.6.4.12
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 20 · 1 record with a druggable one
Structures
7 records of Q6ZQJ5 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5EAN | Crystal structure of Dna2 in complex with a 5' overhang DNA | x-ray diffraction | A | SF4, CA, ADP | — |
| 5EAN | Crystal structure of DNA2 in complex with a 5' overhang DNA | x-ray diffraction | A | — | — |
| 5EAW | Crystal structure of Dna2 nuclease-helicase | x-ray diffraction | A, B | SF4, ADP | 20 (best 0.78) |
| 5EAW | Crystal structure of DNA2 nuclease-helicase | x-ray diffraction | A, B | — | — |
| 5EAX | Crystal structure of Dna2 in complex with an ssDNA | x-ray diffraction | A, B | SF4, ADP | — |
| 5EAX | Crystal structure of DNA2 in complex with an ssdna | x-ray diffraction | A, B | — | — |
| Q6ZQJ5 | AlphaFold monomer V2.0 prediction for DNA replication ATP-dependent HELICASE/NUCLEASE DNA2 (Q6ZQJ5) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5EAW chain B against the predicted model Q6ZQJ5: TM-score 0.97, RMSD 1.77 Å
- 5EAW chain B against the predicted model Q6ZQJ5: TM-score 0.97, RMSD 1.77 Å
- 5EAN chain A against the predicted model Q6ZQJ5: TM-score 0.97, RMSD 1.64 Å
- 5EAN chain A against the predicted model Q6ZQJ5: TM-score 0.97, RMSD 1.64 Å
- 5EAX chain B against the predicted model Q6ZQJ5: TM-score 0.97, RMSD 1.77 Å
- 5EAX chain B against the predicted model Q6ZQJ5: TM-score 0.97, RMSD 1.77 Å
- 5EAX chain A against the predicted model Q6ZQJ5: TM-score 0.97, RMSD 1.75 Å
- 5EAX chain A against the predicted model Q6ZQJ5: TM-score 0.97, RMSD 1.75 Å
- 5EAW chain A against the predicted model Q6ZQJ5: TM-score 0.97, RMSD 1.76 Å
- 5EAW chain A against the predicted model Q6ZQJ5: TM-score 0.97, RMSD 1.76 Å
Elsewhere
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