UniProt Q6QAQ1
Actin, cytoplasmic 1 (Q6QAQ1)
Actin, cytoplasmic 1 (UniProt Q6QAQ1): 17 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 37 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q6QAQ1
- Protein
- Actin, cytoplasmic 1
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 37 · 5 records with a druggable one
Structures
18 records of Q6QAQ1 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ADX | CryoEM structure of dynactin complex at 4.0 angstrom resolution | electron microscopy | H | — | 4 (best 0.84) |
| 5ADX | Cryoem structure of dynactin complex at 4.0 ångström resolution | electron microscopy | H | — | — |
| 5AFU | Cryo-EM structure of dynein tail-dynactin-BICD2N complex | electron microscopy | H | — | — |
| 5AFU | Cryo-EM structure of dynein tail-dynactin-BICD2N complex | electron microscopy | H | — | — |
| 6F1T | Cryo-EM structure of two dynein tail domains bound to dynactin and BICDR1 | electron microscopy | H | ATP | — |
| 6F38 | Cryo-EM structure of two dynein tail domains bound to dynactin and HOOK3 | electron microscopy | H | ATP | 1 (best 0.79) |
| 6F38 | Cryo-EM structure of two dynein tail domains bound to dynactin and HOOK3 | electron microscopy | H | ATP | — |
| 6F3A | Cryo-EM structure of a single dynein tail domain bound to dynactin and BICD2N | electron microscopy | H | ATP | — |
| 6ZNL | Cryo-EM structure of the dynactin complex | electron microscopy | H | ATP | — |
| 6ZNM | The pointed end complex of dynactin bound to BICDR1 | electron microscopy | H | ATP | 5 (best 0.80) |
| 6ZNM | The pointed end complex of dynactin bound to BICDR1 | electron microscopy | H | ATP | — |
| 6ZNN | The pointed end complex of dynactin bound to HOOK3 | electron microscopy | H | ATP | — |
| 6ZNO | The pointed end complex of dynactin with the P150 projection docked | electron microscopy | H | ATP | — |
| 6ZO4 | The pointed end complex of dynactin bound to BICD2 | electron microscopy | H | ATP | 7 (best 0.81) |
| 6ZO4 | The pointed end complex of dynactin bound to BICD2 | electron microscopy | H | ATP | — |
| 7Z8M | The pointed end complex of dynactin bound to BICDR1 | electron microscopy | H | ADP | — |
| 8IB2 | Structure of mammalian spectrin-actin junctional complex of membrane skeleton, Pointed-end segment… | electron microscopy | B, C, D, E, F | ADP | 20 (best 0.80) |
| Q6QAQ1 | AlphaFold monomer V2.0 prediction for actin, cytoplasmic 1 (Q6QAQ1) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7Z8M chain H against the predicted model Q6QAQ1: TM-score 0.96, RMSD 1.36 Å
- 8IB2 chain B against the predicted model Q6QAQ1: TM-score 0.96, RMSD 1.50 Å
- 5ADX chain H against the predicted model Q6QAQ1: TM-score 0.96, RMSD 1.50 Å
- 5AFU chain H against the predicted model Q6QAQ1: TM-score 0.96, RMSD 1.50 Å
- 5ADX chain H against the predicted model Q6QAQ1: TM-score 0.96, RMSD 1.50 Å
- 5AFU chain H against the predicted model Q6QAQ1: TM-score 0.96, RMSD 1.50 Å
- 6F1T chain H against the predicted model Q6QAQ1: TM-score 0.96, RMSD 1.50 Å
- 6ZO4 chain H against the predicted model Q6QAQ1: TM-score 0.96, RMSD 1.43 Å
- 6ZO4 chain H against the predicted model Q6QAQ1: TM-score 0.96, RMSD 1.43 Å
- 6ZNN chain H against the predicted model Q6QAQ1: TM-score 0.96, RMSD 1.43 Å
Elsewhere
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