UniProt Q6PKG0
La-related protein 1 (Q6PKG0)
La-related protein 1 (UniProt Q6PKG0): 14 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 59 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q6PKG0
- Protein
- La-related protein 1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 59 · 13 records with a druggable one
Structures
15 records of Q6PKG0 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4ZC4 | Crystal structure of LARP1-unique domain DM15 | x-ray diffraction | A, B, C, D | SO4 | 6 (best 0.56) |
| 4ZC4 | Crystal structure of LARP1-unique domain DM15 | x-ray diffraction | A, B, C, D | SO4 | 6 (best 0.56) |
| 5C0V | Structure of the LARP1-unique domain DM15 | x-ray diffraction | A, B, C, D | SO4 | 8 (best 0.61) |
| 5C0V | Structure of the LARP1-unique domain DM15 | x-ray diffraction | A, B, C, D | SO4 | 8 (best 0.61) |
| 5V4R | Crystal structure of LARP1-unique domain DM15 bound to m7GTP | x-ray diffraction | A, B | MGT | 2 (best 0.63) |
| 5V4R | Crystal structure of LARP1-unique domain DM15 bound to M7GTP | x-ray diffraction | A, B | MGT | 2 (best 0.63) |
| 5V7C | Crystal structure of LARP1-unique domain DM15 bound 5'TOP RNA sequence | x-ray diffraction | B | — | 1 (best 0.33) |
| 5V7C | Crystal structure of LARP1-unique domain DM15 bound 5'TOP RNA sequence | x-ray diffraction | B | — | 1 (best 0.33) |
| 5V87 | Crystal structure of LARP1-unique domain DM15 bound to m7GpppC | x-ray diffraction | A, B | MGT, 91P | 3 (best 0.63) |
| 5V87 | Crystal structure of LARP1-unique domain DM15 bound to M7GPPPC | x-ray diffraction | A, B | MGT, 91P | 3 (best 0.63) |
| 6PW3 | LARP1 DM15 FYRE (F844Y, R847E) mutant bound to m7GpppG dinucleotide (capG) | x-ray diffraction | C, A, B, D | GTG, MG | 5 (best 0.54) |
| 6PW3 | LARP1 DM15 fyre (F844Y, R847E) mutant bound to M7GPPPG dinucleotide (capg) | x-ray diffraction | C, A, B, D | GTG, MG | 5 (best 0.54) |
| 8XP2 | Cryo-EM structure of the human 40S ribosome with LARP1 | electron microscopy | JD | — | 2 (best 0.88) |
| 8XP3 | Cryo-EM structure of the human 40S ribosome with LARP1 and LRRC47 | electron microscopy | JD | — | 1 (best 0.83) |
| Q6PKG0 | AlphaFold monomer V2.0 prediction for la-related protein 1 (Q6PKG0) | predicted | A | — | 6 (best 0.67) |
Ligands
- MGT · 7N-methyl-8-hydroguanosine-5'-triphosphate · in 4 records
- SO4 · Sulfate ion · in 4 records
- 91P · [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-9-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[(2~{R},3~{S},4~{R},5~{R})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate · in 2 records
- GTG · 7-methyl-guanosine-5'-triphosphate-5'-guanosine · in 2 records
- MG · Magnesium ion · in 2 records
Experiment against prediction
- 5C0V chain C against the predicted model Q6PKG0: TM-score 0.99, RMSD 0.40 Å
- 5C0V chain C against the predicted model Q6PKG0: TM-score 0.99, RMSD 0.40 Å
- 5C0V chain B against the predicted model Q6PKG0: TM-score 0.99, RMSD 0.40 Å
- 5C0V chain B against the predicted model Q6PKG0: TM-score 0.99, RMSD 0.40 Å
- 5V87 chain A against the predicted model Q6PKG0: TM-score 0.99, RMSD 0.42 Å
- 5V87 chain A against the predicted model Q6PKG0: TM-score 0.99, RMSD 0.42 Å
- 5V87 chain B against the predicted model Q6PKG0: TM-score 0.99, RMSD 0.47 Å
- 5V87 chain B against the predicted model Q6PKG0: TM-score 0.99, RMSD 0.47 Å
- 4ZC4 chain C against the predicted model Q6PKG0: TM-score 0.99, RMSD 0.46 Å
- 4ZC4 chain C against the predicted model Q6PKG0: TM-score 0.99, RMSD 0.46 Å
Elsewhere
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