UniProt Q6NZY4
Zinc finger CCHC domain-containing protein 8 (Q6NZY4)
Zinc finger CCHC domain-containing protein 8 (UniProt Q6NZY4): 16 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 69 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q6NZY4
- Protein
- Zinc finger CCHC domain-containing protein 8
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 69 · 8 records with a druggable one
Structures
17 records of Q6NZY4 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LXR | Structure of the minimal RBM7 - ZCCHC8 Complex | x-ray diffraction | B | BR | — |
| 5LXR | Structure of the minimal RBM7 - ZCCHC8 complex | x-ray diffraction | B | BR | — |
| 5LXY | Structure of the minimal RBM7 - ZCCHC8 Complex | x-ray diffraction | D, C, F, H, J, L, N | BR | — |
| 5LXY | Structure of the minimal RBM7 - ZCCHC8 complex | x-ray diffraction | D, C, F, H, J, L, N | BR | — |
| 6C90 | Human Mtr4 helicase in complex with ZCCHC8-CTD | x-ray diffraction | B | — | 4 (best 0.84) |
| 6C90 | Human MTR4 helicase in complex with ZCCHC8-ctd | x-ray diffraction | B | — | — |
| 7S7B | Human Nuclear exosome targeting (NEXT) complex homodimer bound to RNA (substrate 1) | electron microscopy | B, F | ZN | — |
| 7S7B | Human nuclear exosome targeting (next) complex homodimer bound to RNA (substrate 1) | electron microscopy | B, F | ZN | — |
| 7S7C | Human Nuclear Exosome Targeting (NEXT) complex bound to RNA (substrate 2) | electron microscopy | B, F | ZN | 13 (best 0.81) |
| 7S7C | Human nuclear exosome targeting (next) complex bound to RNA (substrate 2) | electron microscopy | B, F | ZN | — |
| 7Z4Y | Human NEXT dimer - overall reconstruction of the core complex | electron microscopy | A, C | — | 6 (best 0.72) |
| 7Z4Y | Human next dimer - overall reconstruction of the core complex | electron microscopy | A, C | — | 6 (best 0.72) |
| 7Z4Z | Human NEXT dimer - focused reconstruction of the dimerization module | electron microscopy | A, C | — | 14 (best 0.61) |
| 7Z4Z | Human next dimer - focused reconstruction of the dimerization module | electron microscopy | A, C | — | 14 (best 0.61) |
| 7Z52 | Human NEXT dimer - focused reconstruction of the single MTR4 | electron microscopy | A | — | 4 (best 0.84) |
| 7Z52 | Human next dimer - focused reconstruction of the single MTR4 | electron microscopy | A | — | 4 (best 0.84) |
| Q6NZY4 | AlphaFold monomer V2.0 prediction for zinc finger cchc domain- containing protein 8 (Q6NZY4) | predicted | A | — | 4 (best 0.38) |
Ligands
Experiment against prediction
- 5LXR chain B against the predicted model Q6NZY4: TM-score 0.76, RMSD 1.58 Å
- 5LXR chain B against the predicted model Q6NZY4: TM-score 0.76, RMSD 1.58 Å
- 5LXY chain J against the predicted model Q6NZY4: TM-score 0.67, RMSD 1.45 Å
- 5LXY chain J against the predicted model Q6NZY4: TM-score 0.67, RMSD 1.45 Å
- 5LXY chain D against the predicted model Q6NZY4: TM-score 0.65, RMSD 1.50 Å
- 5LXY chain D against the predicted model Q6NZY4: TM-score 0.65, RMSD 1.50 Å
- 5LXY chain F against the predicted model Q6NZY4: TM-score 0.64, RMSD 2.02 Å
- 5LXY chain F against the predicted model Q6NZY4: TM-score 0.64, RMSD 2.02 Å
- 5LXY chain N against the predicted model Q6NZY4: TM-score 0.64, RMSD 1.46 Å
- 5LXY chain N against the predicted model Q6NZY4: TM-score 0.64, RMSD 1.46 Å
Elsewhere
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