UniProt Q6N021
Methylcytosine dioxygenase TET2 (Q6N021)
Methylcytosine dioxygenase TET2 (UniProt Q6N021), EC 1.14.11.-: 9 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 30 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q6N021
- Protein
- Methylcytosine dioxygenase TET2
- EC
- 1.14.11.-
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 30 · 4 records with a druggable one
Structures
10 records of Q6N021 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4NM6 | Crystal structure of TET2-DNA complex | x-ray diffraction | A | — | — |
| 4NM6 | Crystal structure of TET2-DNA complex | x-ray diffraction | A | — | — |
| 5D9Y | Crystal structure of TET2-5fC complex | x-ray diffraction | A | OGA, FE, ZN | 6 (best 0.73) |
| 5D9Y | Crystal structure of TET2-5FC complex | x-ray diffraction | A | — | — |
| 5DEU | Crystal structure of TET2-5HMC complex | x-ray diffraction | A | — | — |
| 7NE3 | Human TET2 in complex with favourable DNA substrate. | x-ray diffraction | A | ZN, FE2, OGA | 7 (best 0.72) |
| 7NE3 | Human TET2 in complex with favourable DNA substrate. | x-ray diffraction | A | ZN, FE2, OGA | — |
| 7NE6 | Human TET2 in complex with unfavourable DNA substrate. | x-ray diffraction | A | ZN, OGA, MN | 7 (best 0.74) |
| 7NE6 | Human TET2 in complex with unfavourable DNA substrate. | x-ray diffraction | A | ZN, OGA, MN | — |
| Q6N021 | AlphaFold monomer V2.0 prediction for methylcytosine dioxygenase TET2 (Q6N021) | predicted | A | — | 10 (best 0.71) |
Ligands
Experiment against prediction
- 5DEU chain A against the predicted model Q6N021: TM-score 1.00, RMSD 0.57 Å
- 5D9Y chain A against the predicted model Q6N021: TM-score 0.99, RMSD 0.61 Å
- 5D9Y chain A against the predicted model Q6N021: TM-score 0.99, RMSD 0.61 Å
- 7NE3 chain A against the predicted model Q6N021: TM-score 0.99, RMSD 0.62 Å
- 7NE3 chain A against the predicted model Q6N021: TM-score 0.99, RMSD 0.62 Å
- 4NM6 chain A against the predicted model Q6N021: TM-score 0.99, RMSD 0.64 Å
- 4NM6 chain A against the predicted model Q6N021: TM-score 0.99, RMSD 0.64 Å
- 7NE6 chain A against the predicted model Q6N021: TM-score 0.99, RMSD 0.69 Å
- 7NE6 chain A against the predicted model Q6N021: TM-score 0.99, RMSD 0.69 Å
Elsewhere
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